Evidence map›Paper›PMID 23450206›Full record

ArticleThe International journal of angiology : official publication of the International College of Angiology, Inc2012

Resveratrol, wine, and atherosclerosis.

Kailash Prasad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The International journal of angiology : official publication of the International College of Angiology, Inc, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Alcohol Consumption and Cardiovascular Health.The American journal of medicine · 2022
    Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Tackling Atherosclerosis via Selected Nutrition.International journal of molecular sciences · 2022
    Review
  7. Current Status of Primary, Secondary, and Tertiary Prevention of Coronary Artery Disease.The International journal of angiology : official publication of the International College of Angiology, Inc · 2021
    Review
  8. Article
  9. Review
  10. Review
  11. Red Wine Consumption and Cardiovascular Health.Molecules (Basel, Switzerland) · 2019
    Review
  12. Review
  13. Resveratrol AttenuatesInternational journal of molecular sciences · 2018
    Article
  14. AGE-RAGE Stress, Stressors, and Antistressors in Health and Disease.The International journal of angiology : official publication of the International College of Angiology, Inc · 2018
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Kailash PrasadDepartment of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review emphasizes the effects of resveratrol on factors involved in the mechanism of atherosclerosis and risk factors for atherosclerosis. The effects of wine and resveratrol on atherosclerosis are also discussed. Resveratrol is a potent antioxidant and an anti-inflammatory agent. It reduces the expression of cell adhesion molecules, monocyte colony stimulating factors, matrix metalloproteinases, and growth factors; and inhibits platelet aggregation and vascular smooth muscle cell proliferation. It reduces the serum levels of total cholesterol, triglycerides (TG), and raises high-density lipoprotein cholesterol, inhibits expression of C-reactive protein and lowers the levels of advanced glycation end products and its receptor in the vascular tissue. It lowers the risk factors for plaque rupture. Epidemiological data show that moderate consumption of alcohol has an inverse association with carotid atherosclerosis while high consumption has a positive association with carotid atherosclerosis. Wine reduces the extent of atherosclerosis in animal model. The antiatherosclerotic effect of wine is mainly due to it resveratrol content. Resveratrol reduces the extent of atherosclerosis in animal model of atherosclerosis (apolipoprotein [Apo] E-deficient and Apo E(-/-)/low-density lipoprotein receptor-deficient mice and macrophage). In rabbit model of atherosclerosis, both reduction and acceleration of atherosclerosis have been reported with resveratrol. There are no data for regression and slowing of progression of atherosclerosis. Robust clinical trials for suppression of atherosclerosis are lacking. In conclusion, resveratrol has potential but experimental studies in depth and robust clinical trials are lacking for this agent to be of any value in the primary and secondary prevention of coronary and peripheral artery disease.

Indexed as

atherosclerosisC-reactive proteingrowth factorsinflammatory mediatorsmatrix metalloproteinaseresveratrolserum lipidsvascular smooth muscle cell proliferationwine

Identifiers

PMID23450206
PMCPMC3444029

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.