Evidence map›Paper›PMID 23456209›Full record

Trial reportDiabetologia2013

Associations of objectively measured sedentary behaviour and physical activity with markers of cardiometabolic health.

J Henson, T Yates, S J H Biddle, C L Edwardson, K Khunti, E G Wilmot, L J Gray, T Gorely, M A Nimmo, M J Davies

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 162 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02377037 nacompletednot on this mapstarted 2014, after this paper: background citation

What is the Metabolic Cost of Sitting, Standing, and Sit/Stand Transitions? A Randomized Controlled Trial

TypeinterventionalSponsorTechnical University of LisbonRan2014 to 2015Enrolled50ConditionsMetabolic CostArmsMetabolic cost and HR associated with distinct postural behaviors
NCT02738996 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Investigating the Response of Glycaemic Excursions in Type-2 Diabetes to Interrupting Prolonged Sedentary Behaviour (Sitting)

TypeinterventionalSponsorGlasgow Caledonian UniversityRan2016 to 2017Enrolled24ConditionsDiabetesArmsSedentary time breaks either every 60 minutes, Sedentary time breaks either every 30 minutes, Sedentary time breaks every 15 minutes
3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  6. Sedentary behaviours during pregnancy: a systematic review.The international journal of behavioral nutrition and physical activity · 2017
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  17. Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2014
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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

J HensonDepartment of Cardiovascular Sciences, University of Leicester, Leicester Diabetes Centre, Leicester General Hospital, Leicester LE5 4PW, UK. jjh18@le.ac.uk
T Yates
S J H Biddle
C L Edwardson
K Khunti
E G Wilmot
L J Gray
T Gorely
M A Nimmo
M J Davies

Funding

Department of Health RP-DG-1210-10183Department of Health RP-PG-0606-1272Medical Research Council G0802131
6 · The paper itself

Abstract

aims/hypothesisThe study aimed to examine the associations between objectively measured sedentary time, breaks in sedentary time, moderate-to-vigorous physical activity (MVPA) and total physical activity with markers of cardiometabolic health in a population with known risk factors for type 2 diabetes mellitus.

methodsThis study reports data from two ongoing diabetes prevention programmes. Participants with known risk factors were recruited from primary care practices located within the East Midlands, UK, over the period 2010-2011. ActiGraph GT3X accelerometers (15 s epochs) were used to assess sedentary time (<25 counts per 15 s), MVPA (≥ 488 counts per 15 s) and total physical activity (total counts). A break was considered as any interruption in sedentary time (≥ 25 counts per 15 s). Linear regression examined the independent association of sedentary time, breaks in sedentary time, MVPA and total physical activity with markers of cardiometabolic health.

resultsThe sample comprised 878 participants; 153 from Project STAND (Sedentary Time And Diabetes) (age 32.9 ± 5.6 years, 28.8% male) and 725 from Walking Away from Diabetes (age 63.7 ± 7.8 years, 64.8% male). Following adjustment for various covariates, including MVPA and BMI, there were detrimental linear associations of sedentary time with 2 h plasma glucose (standardised beta coefficient) (β = 0.220, p < 0.001), triacylglycerol (β = 0.206, p = 0.001) and HDL-cholesterol (β = -0.123, p = 0.029). Breaks in sedentary time, total physical activity and MVPA were significantly inversely associated with measures of adiposity, but not with any other cardiometabolic variables after adjustment for sedentary time and BMI. CONCLUSIONS/

interpretationIn adults at high risk of type 2 diabetes mellitus, time spent sedentary is strongly and adversely associated with cardiometabolic health and may be a more important indicator of poor health than MVPA.

Indexed as

Motor ActivitySedentary BehaviorAccelerometryAdiposityAdultAgedBiomarkersBlood GlucoseBody Mass IndexCardiovascular DiseasesCholesterol, HDLCohort StudiesCross-Sectional StudiesDiabetes Mellitus, Type 2EnglandFemaleBiomarkersBlood GlucoseCholesterol, HDLTriglycerides

Identifiers

PMID23456209

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.