Trial reportThe Journal of clinical endocrinology and metabolism2013
Comparison of detection of normal puberty in girls by a hormonal sleep test and a gonadotropin-releasing hormone agonist test.
Trial report in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Randomized, double-blind, dose-escalation trial of triptorelin for ovary protection in childhood-onset systemic lupus erythematosus.Arthritis & rheumatology (Hoboken, N.J.) · 2015Trial
- The maturation of regional sweating patterns from childhood to young adulthood in females.Experimental physiology · 2026Article
- [Application of urinary luteinizing hormone in the prediction of central precocious puberty in girls].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Insulin-like growth factor 1 and sex hormones for assessment of anthropometric and pubertal growth of Egyptian children and adolescents with type 1 diabetes mellitus (single center study).BMC endocrine disorders · 2024Article
- Critical appraisal of diagnostic laboratory tests in the evaluation of central precocious puberty.Frontiers in pediatrics · 2024Article
- Factors Affecting Menstrual Cycle Developmental Trajectory in Adolescents: A Narrative Review.International journal of endocrinology and metabolism · 2022Review
- Normal and Premature Adrenarche.Endocrine reviews · 2021Review
- Longitudinal Investigation of Pubertal Milestones and Hormones as a Function of Body Fat in Girls.The Journal of clinical endocrinology and metabolism · 2021Article
- Polycystic Ovary Syndrome: Ontogeny in Adolescence.Endocrinology and metabolism clinics of North America · 2021Review
- Histrelin Implants for Suppression of Puberty in Youth with Gender Dysphoria: A Comparison of 50 mcg/Day (Vantas) and 65 mcg/Day (SupprelinLA).Transgender health · 2021Article
- Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.PloS one · 2021Article
- Diurnal variation of gonadotropin levels in girls with early stages of puberty.Annals of pediatric endocrinology & metabolism · 2017Article
- The Effect of the Testis on the Ovary: Structure-Function Relationships in a Neonate with a Unilateral Ovotestis (Ovotesticular Disorder of Sex Development) .Hormone research in paediatrics · 2017Article
- Commentary: Launch of a quality improvement network for evidence-based management of uncommon pediatric endocrine disorders: Turner syndrome as a prototype.The Journal of clinical endocrinology and metabolism · 2015Article
- Pubertal onset in girls is strongly influenced by genetic variation affecting FSH action.Scientific reports · 2014Article
- Blunted day-night changes in luteinizing hormone pulse frequency in girls with obesity: the potential role of hyperandrogenemia.The Journal of clinical endocrinology and metabolism · 2014Article
- Morphological changes of gonadotropin-releasing hormone neurons in the rat preoptic area across puberty.Neural regeneration research · 2014Article
- Clinical review: Adolescent anovulation: maturational mechanisms and implications.The Journal of clinical endocrinology and metabolism · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
contextThe magnitude of sleep-related gonadotropin rise required to activate pubertal feminization is not established.
objectiveThe objective of the study was to determine the normal relationship of pubertal hormone responses to sleep and to GnRH agonist (GnRHag) challenge across the female pubertal transition. DESIGN/
settingThis was a prospective study in a General Clinical Research Center.
participantsSixty-two healthy 6- to 13-year-old volunteer girls participated in the study.
interventionsInterventions included overnight blood sampling followed by GnRHag (leuprolide acetate) injection. PRIMARY OUTCOME VARIABLES: The primary outcome variables included LH, FSH, and estradiol.
resultsLH levels rose steadily during sleep and after GnRHag throughout the prepubertal years. The LH response to sleep and GnRHag correlated well across groups (eg, r = 0.807, peak vs 4 h post-GnRHag value); however, this correlation was less robust than in boys (r = 0.964, P < .01). Sleep peak LH of 1.3 U/L or greater had 85% sensitivity and 2.1 U/L or greater 96% specificity for detecting puberty (thelarche). The LH 1-hour post-GnRHag value of 3.2 U/L or greater had 95% sensitivity and 5.5 U/L or greater 96% specificity for detecting puberty. Girls entered puberty at lower LH levels than boys. FSH levels rose day and night during the prepubertal years to reach 1.0 U/L or greater during puberty but discriminated puberty poorly. Estradiol of 34 pg/mL or greater at 20-24 hours after GnRHag was 95% sensitive and 60 pg/mL or greater was 95% specific for puberty. Thirty-six percent of overweight early pubertal girls had meager hormonal evidence of puberty.
conclusionsThese data suggest that sleep-related pubertal hormone levels critical for puberty are normally reflected in the responses to GnRHag testing across the normal female pubertal transition. Inconsistencies between clinical and hormonal staging may arise from peripubertal cyclicity of neuroendocrine function and from excess adiposity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.