ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2013
Sympathetic withdrawal is associated with hypotension after hepatic reperfusion.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Heart rate variability in the clinical assessment of patients with chronic liver disease.World journal of hepatology · 2025Review
- A Review of the Risk Factors and Approaches to Prevention of Post-Reperfusion Syndrome During Liver Transplantation.Organogenesis · 2024Review
- Cardiovascular dysfunction and liver transplantation.Korean journal of anesthesiology · 2018Review
- Acute kidney injury and post-reperfusion syndrome in liver transplantation.World journal of gastroenterology · 2016Review
- Signaling through hepatocyte vasopressin receptor 1 protects mouse liver from ischemia-reperfusion injury.Oncotarget · 2016Article
- Arrhythmogenic potential develops rapidly at graft reperfusion before the start of hypotension during living-donor liver transplantation.Korean journal of anesthesiology · 2016Article
- Post reperfusion syndrome during liver transplantation: From pathophysiology to therapy and preventive strategies.World journal of gastroenterology · 2016Review
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePost-reperfusion syndrome (PRS), severe hypotension after graft reperfusion during liver transplantation, is an adverse clinical event associated with poorer patient outcomes. The purpose of this study was to determine whether alterations in autonomic control in liver transplant recipients prior to graft reperfusion are associated with the subsequent development of PRS.
methodsHeart rate variability (HRV), systolic arterial blood pressure (SBP) variability, and baroreflex sensitivity of 218 liver transplant recipients were evaluated using 5 min of ECG and arterial blood pressure signals 10 min before graft reperfusion along with other clinical parameters. Logistic regression analyses were performed to assess predictors of PRS occurrence.
resultsSeventy-seven patients (35 %) developed PRS while 141 did not. There were significant differences in SBP (110 ± 16 vs. 119 ± 16 mmHg, P < 0.001) and the ratio of low frequency power to high frequency power (LF/HF) of HRV (1.0 ± 1.4 vs. 2.1 ± 3.7, P = 0.003) between the PRS group and No-PRS group. In multivariate logistic regression analysis, predictors were LF/HF (odds ratio 0.817, P = 0.028) and SBP (odds ratio 0.966, P < 0.001).
interpretationLow LF/HF and SBP measured before hepatic graft reperfusion were significantly correlated with subsequent PRS occurrence, suggesting that sympathovagal imbalance and depressed SBP may be key factors predisposing to reperfusion-related severe hypotension in liver transplant recipients.
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