SynthesisAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2013
Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen consortium.
Synthesis in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Mapping shared genetic determinants of eGFR and albuminuria with a focus on type 2 diabetes: a large-scale European study.BMJ open diabetes research & care · 2026Observational
- Familial Variability of Disease Severity in Adult Patients With ADPKD.Kidney international reports · 2024Article
- A Single Nucleotide Polymorphism inCirculation research · 2022Article
- Hypothyroidism and Kidney Function: A Mendelian Randomization Study.Thyroid : official journal of the American Thyroid Association · 2020Article
- Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population.Scientific reports · 2020Article
- The kidney transcriptome, from single cells to whole organs and back.Current opinion in nephrology and hypertension · 2019Review
- Genome-wide association study suggests impact of chromosome 10 rs139401390 on kidney function in patients with coronary artery disease.Scientific reports · 2019Article
- Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy.Physiological reports · 2018Article
- Towards precision nephrology: the opportunities and challenges of genomic medicine.Journal of nephrology · 2018Review
- Atherosclerosis Is an Inflammatory Disease which Lacks a Common Anti-inflammatory Therapy: How Human Genetics Can Help to This Issue. A Narrative Review.Frontiers in pharmacology · 2018Review
- The Genetic Architecture of Coronary Artery Disease: Current Knowledge and Future Opportunities.Current atherosclerosis reports · 2017Review
- Mendelian Randomization as an Approach to Assess Causality Using Observational Data.Journal of the American Society of Nephrology : JASN · 2016Review
- Insights into kidney diseases from genome-wide association studies.Nature reviews. Nephrology · 2016Review
- Cystatin C Predicts Incident Cardiovascular Disease in Twins.Journal of the American Heart Association · 2016Article
- Mendelian Randomisation study of the influence of eGFR on coronary heart disease.Scientific reports · 2016Article
- Parental history of premature cardiovascular disease, estimated GFR, and rate of estimated GFR decline: results from the Aerobics Center Longitudinal Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Observational
- Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC).PloS one · 2015Article
- Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein.PloS one · 2015Article
- Article
- Kidney size and function in a multi-ethnic population-based cohort of school-age children.Pediatric nephrology (Berlin, Germany) · 2014Article
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28 authors at 20 institutions in 7 countries.
Funding
Abstract
backgroundChronic kidney disease is associated with cardiovascular disease. We tested for evidence of a shared genetic basis to these traits. STUDY
designWe conducted 2 targeted analyses. First, we examined whether known single-nucleotide polymorphisms (SNPs) underpinning kidney traits were associated with a series of vascular phenotypes. Additionally, we tested whether vascular SNPs were associated with markers of kidney damage. Significance was set to 1.5×10(-4) (0.05/325 tests). SETTING &
participantsVascular outcomes were analyzed in participants from the AortaGen (20,634), CARDIoGRAM (86,995), CHARGE Eye (15,358), CHARGE IMT (31,181), ICBP (69,395), and NeuroCHARGE (12,385) consortia. Tests for kidney outcomes were conducted in up to 67,093 participants from the CKDGen consortium. PREDICTOR: We used 19 kidney SNPs and 64 vascular SNPs. OUTCOMES & MEASUREMENTS: Vascular outcomes tested were blood pressure, coronary artery disease, carotid intima-media thickness, pulse wave velocity, retinal venular caliber, and brain white matter lesions. Kidney outcomes were estimated glomerular filtration rate and albuminuria.
resultsIn general, we found that kidney disease variants were not associated with vascular phenotypes (127 of 133 tests were nonsignificant). The one exception was rs653178 near SH2B3 (SH2B adaptor protein 3), which showed direction-consistent association with systolic (P = 9.3 ×10(-10)) and diastolic (P = 1.6 ×10(-14)) blood pressure and coronary artery disease (P = 2.2 ×10(-6)), all previously reported. Similarly, the 64 SNPs associated with vascular phenotypes were not associated with kidney phenotypes (187 of 192 tests were nonsignificant), with the exception of 2 high-correlated SNPs at the SH2B3 locus (P = 1.06 ×10(-07) and P = 7.05 ×10(-08)). LIMITATIONS: The combined effect size of the SNPs for kidney and vascular outcomes may be too low to detect shared genetic associations.
conclusionsOverall, although we confirmed one locus (SH2B3) as associated with both kidney and cardiovascular disease, our primary findings suggest that there is little overlap between kidney and cardiovascular disease risk variants in the overall population. The reciprocal risks of kidney and cardiovascular disease may not be genetically mediated, but rather a function of the disease milieu itself.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.