Evidence map›Paper›PMID 23474680›Full record

ReviewNature reviews. Microbiology2013

A cornucopia of human polyomaviruses.

James A DeCaprio, Robert L Garcea

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed, 1 pooled it
20.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

217 citing papers in PubMed, 1 synthesis or guideline pooled it, 359 citations in OpenAlex.

  1. Interventions for BK virus infection in kidney transplant recipients.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Prospective Study of Human Polyomaviruses and Risk of Cutaneous Squamous Cell Carcinoma in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016
    Trial
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  8. Adoptive T-cell therapy for virus-associated diseases.Clinical microbiology reviews · 2025
    Review
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157 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

James A DeCaprioDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. james_decaprio@dfci.harvard.edu
Robert L Garcea
Harvard University · USUniversity of Colorado Boulder · US

Funding

VIRAL ONCOPROTEIN PERTURBATION OF RB/E2F PATHWAYP01CA050661 · NCI · DANA-FARBER CANCER INSTITUTE · PI HAHN, WILLIAM C. · 1989 to 2013
$35.8M
MECHANISMS IN POLYOMA VIRUS ASSEMBLYR01CA037667 · NCI · UNIVERSITY OF COLORADO DENVER · PI GARCEA, ROBERT L · 1985 to 2018
$6.3M
RB-RELATED PROTEINS IN SV4OT AND E1A TRANSFORMATIONR01CA063113 · NCI · DANA-FARBER CANCER INSTITUTE · PI DECAPRIO, JAMES A. · 1994 to 2018
$5.0M
Interaction Between SV40 Large T and P185 CullinR01CA093804 · NCI · DANA-FARBER CANCER INSTITUTE · PI DECAPRIO, JAMES A. · 2002 to 2011
$3.0M
NCI NIH HHS P01 CA050661NCI NIH HHS P01CA050661NCI NIH HHS R01 CA037667NCI NIH HHS R01 CA063113NCI NIH HHS R01 CA093804NCI NIH HHS R01CA37667NCI NIH HHS R01CA63113NCI NIH HHS R01CA93804
6 · The paper itself

Abstract

During the past 6 years, focused virus hunting has led to the discovery of nine new human polyomaviruses, including Merkel cell polyomavirus, which has been linked to Merkel cell carcinoma, a lethal skin cell cancer. The discovery of so many new and highly divergent human polyomaviruses raises key questions regarding their evolution, tropism, latency, reactivation, immune evasion and contribution to disease. This Review describes the similarities and differences among the new human polyomaviruses and discusses how these viruses might interact with their human host.

Indexed as

AnimalsBiological EvolutionCarcinoma, Merkel CellGenome, ViralHost-Pathogen InteractionsHumansMerkel cell polyomavirusPhylogenyPolyomavirusPolyomavirus InfectionsPrimatesSkin NeoplasmsTumor Virus InfectionsViral Tropism

Identifiers

PMID23474680
PMCPMC3928796
OpenAlexW1993923591

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.