Evidence map›Paper›PMID 23507920›Full record

ReviewBiomatter

Encapsulated stem cells for cancer therapy.

Khalid Shah

Open access · hybridAbstract readReview
In one paragraph

Review in Biomatter. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
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  7. Monitoring and modulation of the tumor microenvironment for enhanced cancer modeling.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Khalid ShahMolecular Neurotherapy and Imaging Laboratory; Massachusetts General Hospital; Harvard Medical School; Boston, MA USA; Department of Radiology; Massachusetts General Hospital; Harvard Medical School; Boston, MA USA; Department of Neurology; Massachusetts General Hospital; Harvard Medical School; Boston, MA USA; Harvard Stem Cell Institute; Harvard University; Cambridge, MA USA.
Harvard University · US

Funding

In vivo imaging of encapsulated stem cells in mouse models of tumor resectionR01CA173077 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SHAH, KHALID A · 2013 to 2017
$1.7M
Developing diagnostic and therapeutic stem cells for cancer therapyR01CA138922 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SHAH, KHALID A · 2010 to 2014
$1.7M
Stem cell mediated targeting of tumor cells and associated vasculature in gliomasR01NS071197 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SHAH, KHALID A · 2011 to 2014
$1.5M
NCI NIH HHS CA138922NCI NIH HHS CA173077NCI NIH HHS R01 CA138922NCI NIH HHS R01 CA173077NINDS NIH HHS NS071197NINDS NIH HHS R01 NS071197
6 · The paper itself

Abstract

Stem cells have inherent tumor‑trophic migratory properties and can serve as vehicles for delivering effective, targeted therapy to isolated tumors and metastatic disease, making them promising anti‑cancer agents. Encapsulation of therapeutically engineered stem cells in hydrogels has been utilized to provide a physical barrier to protect the cells from hostile extrinsic factors and significantly improve the therapeutic efficacy of transplanted stem cells in different models of cancer. This review aims to discuss the potential of different stem cell types for cancer therapy, various engineered stem cell based therapies for cancer, stem cell encapsulation process and provide an in depth overview of current applications of therapeutic stem cell encapsulation in the highly malignant brain tumor, glioblastoma multiforme (GBM), as well as the prospects for their clinical translation.

Indexed as

AnimalsAntineoplastic AgentsBiocompatible MaterialsCapsulesExtracellular MatrixGenetic TherapyHumansHyaluronic AcidHydrogelsNeoplasmsStem CellsStem Cell TransplantationTissue EngineeringAntineoplastic AgentsBiocompatible MaterialsCapsulesHyaluronic AcidHydrogelsimagingsECMstem cellsTRAILtumors

Identifiers

PMID23507920
PMCPMC3732324
OpenAlexW2171656760

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.