ArticleNeuroscience2013
Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus-estrus transition.
Article in Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Sexual dimorphism of the ventral premammillary nucleus of the rat: stereological evaluation.Biology of sex differences · 2025Article
- Article
- Nutritionally Responsive PMv DAT Neurons Are Dynamically Regulated During Pubertal Transition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- CART Neurons in the Hypothalamic Ventral Premammillary Nucleus (PMv) in Rats Mediate Maternal, But Not Inter-male Aggression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Nutritionally responsive PMv DAT neurons are dynamically regulated during pubertal transition.bioRxiv : the preprint server for biology · 2025Article
- Nesfatin-1 Neurons in the Ventral Premammillary Nucleus Integrate Metabolic and Reproductive Signals in Male Rats.International journal of molecular sciences · 2025Article
- The ventral premammillary nucleus at the interface of environmental cues and social behaviors.Frontiers in neuroscience · 2025Review
- Article
- Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin.Brain structure & function · 2019Article
- Exome Sequencing Reveals the POLR3H Gene as a Novel Cause of Primary Ovarian Insufficiency.The Journal of clinical endocrinology and metabolism · 2019Article
- Sexually dimorphic distribution of Prokr2 neurons revealed by the Prokr2-Cre mouse model.Brain structure & function · 2017Article
- The role of leptin in health and disease.Temperature (Austin, Tex.) · 2017Review
- AMPKα2 in Kiss1 Neurons Is Required for Reproductive Adaptations to Acute Metabolic Challenges in Adult Female Mice.Endocrinology · 2016Article
- Genetic Isolation of Hypothalamic Neurons that Regulate Context-Specific Male Social Behavior.Cell reports · 2016Article
- 20 years of leptin: leptin and reproduction: past milestones, present undertakings, and future endeavors.The Journal of endocrinology · 2014Review
- Distribution of the neuronal inputs to the ventral premammillary nucleus of male and female rats.Brain research · 2014Article
- A critical view of the use of genetic tools to unveil neural circuits: the case of leptin action in reproduction.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Review
- Role of GnRH Neurons and Their Neuronal Afferents as Key Integrators between Food Intake Regulatory Signals and the Control of Reproduction.International journal of endocrinology · 2013Review
- Effects of growth hormone in the central nervous system.Archives of endocrinology and metabolismReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
We have recently demonstrated that the ventral premammillary nucleus (PMV) plays a key role in the metabolic control of the female reproductive axis. However, whether PMV neurons modulate the reproductive neural circuitry and/or the expression of sexual behaviors has not been determined. Here, we showed that the expression of estrogen and progesterone receptors in the PMV is modulated by changing levels of sex steroids across the estrous cycle. We also showed that sexual behavior, not the high physiologic levels of sex steroids, induces Fos in PMV neurons. Bilateral lesions of the PMV caused no significant changes in proceptive behavior but a high percentage of PMV-lesioned rats failed to exhibit lordosis behavior when exposed to a sexually experienced male rat (50% vs. 18% in the control group). Notably, lesions of the PMV disrupted the physiologic fluctuations of Kiss1 and GnRH mRNA expression characteristic of the proestrus-to-estrus transition. This neurochemical imbalance may ultimately alter female reproductive behavior. Our findings suggest that the PMV is a component of the neural circuitry that modulates the physiologic fluctuations of key neuroendocrine players (i.e., Kiss1 and GnRH) in the control of the female reproductive physiology.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.