ArticleCirculation. Cardiovascular imaging2013
Prevalence and predictors of ischemia and outcomes in outpatients with diabetes mellitus referred for single-photon emission computed tomography myocardial perfusion imaging.
Article in Circulation. Cardiovascular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Prognostic value of SPECT myocardial perfusion entropy in high-risk type 2 diabetic patients.European journal of nuclear medicine and molecular imaging · 2021Trial
- Sex-based differences in myocardial perfusion imaging among diabetic Egyptian patients:a retrospective registry study.Global cardiology science & practice · 2026Article
- Cardiovascular Magnetic Resonance Imaging as an Adjunct to the Evaluation of Cardiovascular Involvement in Diabetes Mellitus.Journal of personalized medicine · 2023Review
- Rise and fall, and provisional rebirth of exercise stress testing at the dawn of the third millennium.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Long-term outcomes in patients with normal coronary arteries, nonobstructive, or obstructive coronary artery disease on invasive coronary angiography.Clinical cardiology · 2021Article
- Safety measures and clinical outcome of Nuclear Cardiology Department during Covid-19 lockdown pandemic: Northern Italy experience.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Whole-heart, ungated, free-breathing, cardiac-phase-resolved myocardial perfusion MRI by using Continuous Radial Interleaved simultaneous Multi-slice acquisitions at sPoiled steady-state (CRIMP).Magnetic resonance in medicine · 2020Article
- Delayed Galectin-3-Mediated Reprogramming of Microglia After Stroke is Protective.Molecular neurobiology · 2019Article
- Non-Invasive Imaging in Diabetic Cardiomyopathy.Journal of cardiovascular development and disease · 2019Review
- Clinical Characteristics, Sex Differences, and Outcomes in Patients With Normal or Near-Normal Coronary Arteries, Non-Obstructive or Obstructive Coronary Artery Disease.Journal of the American Heart Association · 2018Article
- Integrating Biomarkers and Imaging for Cardiovascular Disease Risk Assessment in Diabetes.Current cardiology reports · 2016Review
- Cardiovascular Disease Risk Assessment: Review of Established and Newer Modalities.Current treatment options in cardiovascular medicine · 2015Article
- Screening asymptomatic patients with type 2 diabetes: The debates persist.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Value of Exercise ECG for Risk Stratification in Suspected or Known CAD in the Era of Advanced Imaging Technologies.JACC. Cardiovascular imaging · 2015Review
- Contemporary relevance of TID: Based on the company it keeps.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Cardiovascular risk stratification in diabetic patients following stress single-photon emission-computed tomography myocardial perfusion imaging: the impact of achieved exercise level.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Cardiovascular risk stratification in diabetic patients: is all in METS?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Assessing the prognostic implications of myocardial perfusion studies: identification of patients at risk vs patients who may benefit from intervention?Current cardiology reports · 2014Review
- Decrease in the frequency of stress-induced ischemia over the past two decades.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
- Microalbuminuria (Moderate Albumin Excretion) and its relationship with Silent myocardial ischemia in treatment naïve type II diabetic patients.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Background- The prevalence of ischemia and its prediction of events are unclear in outpatients with diabetes mellitus in the modern era of intensive medical management. We sought to identify the prevalence of ischemia, subsequent cardiac events, and impact of sex, stress type, and symptom status on these findings in a cohort of stable outpatients with diabetes mellitus referred for single-photon emission computed tomography myocardial perfusion imaging (MPI). Methods and Results- The study cohort included 575 consecutive outpatients with diabetes mellitus who underwent quantitative, gated single-photon emission computed tomography MPI. Clinical information, stress MPI variables, and cardiac events were prospectively collected and analyzed. The study population was at intermediate risk of coronary artery disease or had known coronary artery disease (40.3%); 29% of patients were asymptomatic at the time of stress testing. Scintigraphic ischemia and significant (≥10%) left ventricular ischemia were present in 126 patients (21.9%) and 29 patients (5.0%), respectively, and <1% of patients had early revascularization. The risk of ischemia was increased >2-fold by male sex (P<0.001), but was not impacted by pharmacological stress (P=0.15) or presence of symptoms (P=0.89). During a median 4.4 years follow-up, the rate of cardiac death/nonfatal myocardial infarction was moderate at 2.6%/y (cardiac death 0.8%/y) in the total cohort, but was 5.7%/y in those with ischemia (P<0.001). Pharmacological stress predicted a higher cardiac event rate (P<0.001) but symptoms did not (P=0.55). Conclusions- This cohort of stable outpatients with diabetes mellitus referred for single-photon emission computed tomography had low rates of significant ischemia and early revascularization; an initially low cardiac event rate increased after 2 years. Independent predictors of cardiac death/nonfatal myocardial infarction were known coronary artery disease, pharmacological stress, and MPI ischemia. Nearly one third of those with events had a normal MPI, indicating a need for improved risk stratification.
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Registered trials
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