Evidence map›Paper›PMID 23550085›Full record

ArticleJournal of diabetes investigation2013

Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease.

Aaron I Vinik, Tomris Erbas, Carolina M Casellini

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04100486 (A Pilot Study to Quantify the Autonomic Nervous System Balance in Healthy, Able-Bodied Individuals), which is not on this map. Cited by 162 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04100486 enrolling by invitationnot on this mapstarted 2019, after this paper: background citation

A Pilot Study to Quantify the Autonomic Nervous System Balance in Healthy, Able-Bodied Individuals

TypeobservationalSponsorNorthwell HealthRan2019 to 2027Enrolled48ConditionsAutonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic DisorderArmsStanding-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test, Cold Face Test, Valsalva Maneuver
3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Increased fall risk in people with type 2 diabetes and cardiovascular disease: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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  8. The hemodynamic and pain impact of peripheral nerve block versus spinal anesthesia in diabetic patients undergoing diabetic foot surgery.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020
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  10. Minocycline improves peripheral and autonomic neuropathy in type 2 diabetes: MIND study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014
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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aaron I VinikThe Strelitz Diabetes Research Center and Neuroendocrine Unit, The Department of Medicine and Pathology/Anatomy/Neurobiology, Eastern Virginia Medical School Norfolk, Virginia, USA.
Tomris Erbas
Carolina M Casellini

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the most overlooked of all serious complications of diabetes is cardiovascular autonomic neuropathy. There is now clear evidence that suggests activation of inflammatory cytokines in diabetic patients and that these correlate with abnormalities in sympathovagal balance. Dysfunction of the autonomic system predicts cardiovascular risk and sudden death in patients with type 2 diabetes. It also occurs in prediabetes, providing opportunities for early intervention. Simple tests that can be carried out at the bedside with real-time output of information - within the scope of the practicing physician - facilitate diagnosis and allow the application of sound strategies for management. The window of opportunity for aggressive control of all the traditional risk factors for cardiovascular events or sudden death with intensification of therapy is with short duration diabetes, the absence of cardiovascular disease and a history of severe hypoglycemic events. To this list we can now add autonomic dysfunction and neuropathy, which have become the most powerful predictors of risk for mortality. It seems prudent that practitioners should be encouraged to become familiar with this information and apply risk stratification in clinical practice. Several agents have become available for the correction of functional defects in the autonomic nervous system, and restoration of autonomic balance is now possible.

Indexed as

Cardiac autonomic neuropathyInflammationPathogenesis

Identifiers

PMID23550085
PMCPMC3580884

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.