ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
CaMKII-dependent phosphorylation of the GTPase Rem2 is required to restrict dendritic complexity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus.bioRxiv : the preprint server for biology · 2024Article
- Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus.PloS one · 2024Article
- The evolution of mammalian Rem2: unraveling the impact of purifying selection and coevolution on protein function, and implications for human disorders.Frontiers in bioinformatics · 2024Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Experience-Dependent Development of Dendritic Arbors in Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- CaMKII controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles.PLoS biology · 2020Article
- TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest.eLife · 2019Article
- The Ras-like GTPase Rem2 is a potent inhibitor of calcium/calmodulin-dependent kinase II activity.The Journal of biological chemistry · 2018Article
- Neural architecture: from cells to circuits.Journal of neurophysiology · 2018Review
- Article
- Rem2 signaling affects neuronal structure and function in part by regulation of gene expression.Molecular and cellular neurosciences · 2017Article
- TDP-43 misexpression causes defects in dendritic growth.Scientific reports · 2017Article
- Rad GTPase is essential for the regulation of bone density and bone marrow adipose tissue in mice.Bone · 2017Article
- A Novel HumanThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Localization of rem2 in the central nervous system of the adult rainbow trout (Oncorhynchus mykiss).Journal of chemical neuroanatomy · 2016Article
- Rem2, a member of the RGK family of small GTPases, is enriched in nuclei of the basal ganglia.Scientific reports · 2016Article
- Regulation of dendrite morphogenesis by extrinsic cues.Trends in neurosciences · 2015Review
- Nerve injury induces a Gem-GTPase-dependent downregulation of P/Q-type Ca2+ channels contributing to neurite plasticity in dorsal root ganglion neurons.Pflugers Archiv : European journal of physiology · 2015Article
- Molecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteins.Trends in neurosciences · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The morphogenesis of the dendritic arbor is a critical aspect of neuronal development, ensuring that proper neural networks are formed. However, the molecular mechanisms that underlie this dendritic remodeling remain obscure. We previously established the activity-regulated GTPase Rem2 as a negative regulator of dendritic complexity. In this study, we identify a signaling pathway whereby Rem2 regulates dendritic arborization through interactions with Ca(2+)/calmodulin-dependent kinases (CaMKs) in rat hippocampal neurons. Specifically, we demonstrate that Rem2 functions downstream of CaMKII but upstream of CaMKIV in a pathway that restricts dendritic complexity. Furthermore, we show that Rem2 is a novel substrate of CaMKII and that phosphorylation of Rem2 by CaMKII regulates Rem2 function and subcellular localization. Overall, our results describe a unique signal transduction network through which Rem2 and CaMKs function to restrict dendritic complexity.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.