Evidence map›Paper›PMID 23598457›Full record

ArticleArquivos brasileiros de cardiologia2013

Unrecognized diabetes and myocardial necrosis: predictors of hyperglycemia in myocardial infarction.

Renata Teixeira Ladeira, Luciano Moreira Baracioli, Tanize Espírito Santo Faulin, Dulcinéia Saes Parra Abdalla, Talita Matttos Seydell, Raul Cavalcante Maranhão, Berenice Bilharinho Mendonça, Célia Cassaro Strunz, Isac de Castro, José Carlos Nicolau

Registry-linked trialOpen access · diamondAbstract read
PubMed
In one paragraph

Article in Arquivos brasileiros de cardiologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06286878 (Pleiotropic Effects of Dapagliflozin in Patients With Acute Coronary Syndromes), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06286878 phase2 / phase3recruitingstarted 2021, after this paper: background citation

Pleiotropic Effects of Dapagliflozin in Patients With Acute Coronary Syndromes

Ran2021Enrolled80Registered outcomes4Posted comparisons0ConditionsAcute Coronary Syndrome, Diabetes, Myocardial Infarction, Ventricular DysfunctionArmsdapagliflozin, Placebo
PMID 14502100PMID 28605608PMID 21205121PMID 26026848PMID 27295427PMID 28522450PMID 11602624PMID 27679584PMID 27470878PMID 31736328PMID 9353988PMID 8853630other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Renata Teixeira LadeiraInstituto do Coração (InCor) – Hospital da Clínicas da Faculdade de Medicina da Universidade de São Paulo, SP, Brazil. rtlad@cardiol.br
Luciano Moreira Baracioli
Tanize Espírito Santo Faulin
Dulcinéia Saes Parra Abdalla
Talita Matttos Seydell
Raul Cavalcante Maranhão
Berenice Bilharinho Mendonça
Célia Cassaro Strunz
Isac de Castro
José Carlos Nicolau
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyperglycemia in the acute phase of myocardial infarction is an important prognostic factor. However, its pathophysiology is not fully understood.

objectiveTo analyze simultaneously the correlation between hyperglycemia and biochemical markers related to stress, glucose and lipid metabolism, coagulation, inflammation, and myocardial necrosis. METHODS Eighty patients with acute myocardial infarction were prospectively included. The following parameters were analyzed: blood glucose; stress hormones (cortisol and norepinephrine); glucose metabolism factors [glycated hemoglobin (HbA1c); insulin]; lipoproteins (total cholesterol, LDL, HDL, minimally modified electronegative LDL, and adiponectin); glycerides (triglycerides, VLDL and fatty acids); coagulation factors (factor VII, fibrinogen, plasminogen activator inhibitor-1); inflammation (high-sensitivity C reactive protein); and myocardial necrosis (CK-MB and troponin). Continuous variables were converted into degrees of relevance using fuzzy logic.

resultsSignificant correlation was observed between hyperglycemia and glucose metabolism (p < 0.001), lipoproteins (p = 0.03), and necrosis factors (p = 0.03). In the multivariate analysis, only glucose metabolism (OR = 4.3; CI = 2.1-68.9; and p < 0.001) and myocardial necrosis (OR = 22.5; CI = 2-253; and p = 0.012) showed independent and significant correlation. For the analysis of the influence of history of diabetes mellitus, a regression model including only patients without diabetes mellitus was developed, and the results did not change. Finally, in the model adjusted for age, gender, and clinical variables (history of diabetes mellitus, hypertension and dyslipidemia), three variables maintained a significant and independent association with hyperglycemia: glucose metabolism (OR = 24.1; CI = 4.8-122.1; and p < 0.001), myocardial necrosis (OR = 21.9; CI = 1.3-360.9; and p = 0.03), and history of DM (OR = 27; CI = 3.7-195.7; and p = 0.001).

conclusionGlucose metabolism and myocardial necrosis markers were the best predictors of hyperglycemia in patients with acute myocardial infarction.

Indexed as

BiomarkersBlood CoagulationCreatine Kinase, MB FormDiabetes MellitusEpidemiologic MethodsFemaleGlycated HemoglobinHumansHyperglycemiaInflammationInsulinLipoproteinsMaleMiddle AgedMyocardial InfarctionNecrosisBiomarkersCreatine Kinase, MB FormGlycated HemoglobinInsulinLipoproteinsTroponin

Identifiers

PMID23598457
OpenAlexW2134425769

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.