ArticleCase reports in neurological medicine2013
Multidisciplinary management of a giant plexiform neurofibroma by double sequential preoperative embolization and surgical resection.
Article in Case reports in neurological medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Surgical management of plexiform neurofibromas: An imaging-based perioperative framework.JPRAS open · 2026Review
- Staged Resection and Reconstruction of a 60-kg Giant Plexiform Neurofibroma Involving the Posterior Trunk and Thigh.Plastic and reconstructive surgery. Global open · 2026Article
- Outcome of Surgical Intervention in Giant Neurofibromas in Two Sisters with Neurofibromatosis Type 1: A Case Series and Literature Review.Clinical, cosmetic and investigational dermatology · 2026Article
- Giant Atypical Neurofibroma of the Calf in Neurofibromatosis Type 1: Case Report and Literature Review.Reports (MDPI) · 2025Article
- Case report: Remarkable efficacy of negative-pressure wound therapy in giant lower extremity elephantiasis neuromatosa for vascularization, skin grafting, and fluid control.International journal of surgery case reports · 2024Article
- Hemorrhagic Complication in Surgical Resection for Massive Plexiform Neurofibroma in Body Trunk: The Flow-Void Sign as a Predictor and Preoperative Embolization as Prevention.World journal of surgery · 2021Article
- A 63-kg giant neurofibroma in the right lower extremity and gluteal region of a 22-year-old woman: A case report.Clinical case reports · 2021Article
- Article
- Surgery combined with embolization in the treatment of plexiform neurofibroma: Case report and literature review.JAAD case reports · 2020Article
- Giant Plexiform Neurofibroma of the Perineum and Pelvic Cavity Manifesting as Segmental Neurofibromatosis.Annals of dermatology · 2019Article
- Hybrid resection of a giant thigh plexiform neurofibroma.International journal of surgery case reports · 2015Article
- Arteriovenous Malformation Underlying a Plexiform Neurofibroma: An Unusual Presentation.Indian dermatology online journalArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plexiform neurofibromas are benign tumors originating from subcutaneous or visceral peripheral nerves, which are usually associated with neurofibromatosis type 1. Giant neurofibromas are very difficult to manage surgically as they are extensively infiltrative and highly vascularized. These types of lesions require complex preoperative and postoperative management strategies. This case report describes a 22-year-old female with a giant plexiform neurofibroma of the lower back and buttock who underwent pre-operative embolization and intraoperative use of a linear cutting stapler system to assist with haemostasis during the surgical resection. Minimal blood transfusion was required and the patient made a good recovery. This case describes how a multidisciplinary management of these large and challenging lesions is technically feasible and appears to be beneficial in reducing perioperative blood loss and morbidity. Giant neurofibroma is a poorly defined term used to describe a neurofibroma that has grown to a significant but undefined size. Through a literature review, we propose that the term "giant neurofibroma" be used for referring to those neurofibromas weighing 20% or more of the patient's total corporal weight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.