ArticleCirculation. Cardiovascular quality and outcomes2013
Walking impairment questionnaire improves mortality risk prediction models in a high-risk cohort independent of peripheral arterial disease status.
Article in Circulation. Cardiovascular quality and outcomes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06566976 (Prehabilitation and Rehabilitation in PAD), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prehabilitation and Rehabilitation in PAD: A Randomized Exercise Intervention Trial (PREPARE-IT)
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Association of lower extremity performance with cardiovascular and all-cause mortality in patients with peripheral artery disease: a systematic review and meta-analysis.Journal of the American Heart Association · 2014Pooled it
- Association of social support and health status outcomes in peripheral artery disease.Journal of vascular surgery · 2024Article
- Exercise Therapy in the Management of Peripheral Arterial Disease.Mayo Clinic proceedings. Innovations, quality & outcomes · 2023Review
- Impact of the COVID-19 pandemic on health lifestyle in patients with peripheral artery disease: A cross-sectional study.Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing · 2022Article
- Tibio-pedal arterial pressure assessment during endovascular intervention to improve quality-of-life in patients with intermittent claudication.Frontiers in cardiovascular medicine · 2022Article
- Unsupervised Learning for Automated Detection of Coronary Artery Disease Subgroups.Journal of the American Heart Association · 2021Article
- Predicting in-hospital mortality of patients with febrile neutropenia using machine learning models.International journal of medical informatics · 2020Article
- A prospective community engagement initiative to improve clinical research participation in patients with peripheral artery disease.SAGE open medicine · 2020Article
- Evaluation and treatment of patients with lower extremity peripheral artery disease: consensus definitions from Peripheral Academic Research Consortium (PARC).Journal of the American College of Cardiology · 2015Article
- Effect of physical activity assessment on prognostication for peripheral artery disease and mortality.Mayo Clinic proceedings · 2015Article
- The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model.Vascular medicine (London, England) · 2014Article
- Article
- Alternative ankle-brachial index method identifies additional at-risk individuals.Journal of the American College of Cardiology · 2013Article
- Low Walking Impairment Questionnaire score after a recent myocardial infarction identifies patients with polyvascular disease.JRSM cardiovascular diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe Walking Impairment Questionnaire (WIQ) is a subjective measure of patient-reported walking performance developed for peripheral arterial disease. The purpose of this study is to examine whether this simple tool can improve the predictive capacity of established risk models and whether the WIQ can be used in patients without peripheral arterial disease. METHODS AND
resultsAt baseline we assessed the walking distance, stair-climbing, and walking speed WIQ category scores among individuals who were undergoing coronary angiography. During a median follow-up of 5.0 years, there were 172 mortalities among 1417 study participants. Adjusted Cox proportional hazards models showed that all 3 WIQ categories independently predicted future all-cause and cardiovascular mortality, including among individuals without peripheral arterial disease (P<0.001). Compared with the cardiovascular risk factors model, we observed significantly increased risk discrimination with a C-index of 0.741 (change in C-index, 0.040; 95% confidence interval, 0.011-0.068) and 0.832 (change in C-index, 0.080; 95% confidence interval, 0.034-0.126) for all-cause and cardiovascular mortality, respectively. Examination of risk reclassification using the net reclassification improvement index showed a 48.4% (P<0.001) improvement for all-cause mortality and a 77.4% (P<0.001) improvement for cardiovascular mortality compared with the cardiovascular risk factors model.
conclusionsAll 3 WIQ categories independently predicted future all-cause and cardiovascular mortality. Importantly, we found that this subjective measure of walking ability could be extended to patients without peripheral arterial disease. The addition of the WIQ scores to established cardiovascular risk models significantly improved risk discrimination and reclassification, suggesting broad clinical use for this simple, inexpensive test.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.