Evidence map›Paper›PMID 23647804›Full record

Trial reportClinical breast cancer2013

Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors.

Shelli Kesler, S M Hadi Hosseini, Charles Heckler, Michelle Janelsins, Oxana Palesh, Karen Mustian, Gary Morrow

5 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical breast cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 133 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 11 pooled it
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02592070 nacompletednot on this mapstarted 2015, after this paper: background citation

Activity & Cognition After Treatment (ACT) for Breast Cancer

TypeinterventionalSponsorUniversity of Illinois at Urbana-ChampaignRan2015 to 2016Enrolled31ConditionsBreast Cancer, Mild Cognitive Impairment, Physical ActivityArmsWalking
NCT03017560 nacompletednot on this mapstarted 2015, after this paper: background citation

Treating Verbal Memory Deficits Following Chemotherapy for Breast Cancer

TypeinterventionalSponsorNorthwestern UniversityRan2015 to 2017Enrolled45ConditionsBreast Cancer Treatment, Cognitive DeficitsArmsComputerized cognitive treatment
NCT03621397 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

The Effectiveness of an Online Spanish Cognitive Intervention Program for Spanish-Speaking Latino/Hispanic Subarachnoid Hemorrhage Patients

TypeinterventionalSponsorDHR Health Institute for Research and DevelopmentRan2021 to 2022Enrolled0ConditionsSubarachnoid Hemorrhage, Cognitive Impairment, Quality of Life, Depression, AnxietyArmsbrainHQ by Posit Science
NCT04616300 recruitingnot on this mapstarted 2019, after this paper: background citation

Cardiorespiratory Fitness, Inflammatory Biomarkers, and Cognitive Function Patterns During Treatment for Breast Cancer: a Prospective Cohort Study

Typeobservational_patient_registrySponsorUniversity of TorontoRan2019 to 2025Enrolled50ConditionsBreast Cancer
NCT05704855 nacompletednot on this mapstarted 2023, after this paper: background citation

A Remotely-Delivered, Combined Exercise Training Program for Cognitive Function in Women Living With and Beyond Breast Cancer: A Feasibility Study

TypeinterventionalSponsorUniversity of TorontoRan2023 to 2023Enrolled21ConditionsBreast CancerArmsCombined Exercise + Behavioural Counselling, Active Control
3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 11 syntheses or guidelines pooled it, 296 citations in OpenAlex.

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  5. Computerized programs for cancer survivors with cognitive problems: a systematic review.Journal of cancer survivorship : research and practice · 2019
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  6. Psychostimulants for cancer-related cognitive impairment in adult cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  7. Neuropsychological disorders in non-central nervous system cancer: a review of objective cognitive impairment, depression, and related rehabilitation options.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
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  20. Nicotinic treatment of post-chemotherapy subjective cognitive impairment: a pilot study.Journal of cancer survivorship : research and practice · 2019
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73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shelli KeslerDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94305-5795, USA. skesler@stanford.edu
S M Hadi Hosseini
Charles Heckler
Michelle Janelsins
Oxana Palesh
Karen Mustian
Gary Morrow
University of Rochester · USStanford University · USStanford Medicine · US

Funding

Assessment and Treatment of Cognitive Deficits in Breast CancerDP2OD004445 · OD · STANFORD UNIVERSITY · PI KESLER, SHELLI R · 2008 to 2008
$2.4M
Interventions Targeting Inflammation for Chemotherapy-Related Cognitive ProblemsK07CA168886 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C · 2013 to 2017
$724k
NCI NIH HHS K07 CA168886NIH HHS 1DP2 OD004445-01NIH HHS DP2 OD004445
6 · The paper itself

Abstract

backgroundA majority of breast cancer (BC) survivors, particularly those treated with chemotherapy, experience long-term cognitive deficits that significantly reduce quality of life. Among the cognitive domains most commonly affected include executive functions (EF), such as working memory, cognitive flexibility, multitasking, planning, and attention. Previous studies in other populations have shown that cognitive training, a behavioral method for treating cognitive deficits, can result in significant improvements in a number of cognitive skills, including EF. MATERIALS AND

methodsIn this study, we conducted a randomized controlled trial to investigate the feasibility and preliminary effectiveness of a novel, online EF training program in long-term BC survivors. A total of 41 BC survivors (21 active, 20 wait list) completed the 48 session training program over 12 weeks. The participants were, on average, 6 years after therapy.

resultsCognitive training led to significant improvements in cognitive flexibility, verbal fluency and processing speed, with marginally significant downstream improvements in verbal memory as assessed via standardized measures. Self-ratings of EF skills, including planning, organizing, and task monitoring, also were improved in the active group compared with the wait list group.

conclusionsOur findings suggest that EF skills may be improved even in long-term survivors by using a computerized, home-based intervention program. These improvements may potentially include subjective EF skills, which suggest a transfer of the training program to real-world behaviors.

Indexed as

Executive FunctionHealth PromotionAdultBreast NeoplasmsCognition DisordersCognitive Behavioral TherapyFeasibility StudiesFemaleFollow-Up StudiesHumansMiddle AgedPrognosisQuality of LifeSurvivorsChemotherapyCognitive flexibilityMemoryProcessing speedRehabilitation

Identifiers

PMID23647804
PMCPMC3726272
OpenAlexW1988359564

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.