ArticleAutoimmunity reviews2013
Potential role of human-specific genes, human-specific microRNAs and human-specific non-coding regulatory RNAs in the pathogenesis of systemic sclerosis and Sjögren's syndrome.
Article in Autoimmunity reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Relationship of miRNA-146a to primary Sjögren's syndrome and to systemic lupus erythematosus: a meta-analysis.Rheumatology international · 2017Pooled it
- An Exploration of the Role of MicroRNAs in Psoriasis: A Systematic Review of the Literature.Medicine · 2015Pooled it
- Role of Micro RNAs in the Pathogenesis of Rheumatoid Arthritis: Novel Perspectives Based on Review of the Literature.Medicine · 2015Pooled it
- Circulating microRNA203 and its target genes' role in psoriasis pathogenesis.Frontiers in medicine · 2022Article
- PI3K/AKT/mTOR Signaling Pathway Is Downregulated by Runzaoling (RZL) in Sjögren's Syndrome.Mediators of inflammation · 2022Article
- Global gene expression analysis of systemic sclerosis myofibroblasts demonstrates a marked increase in the expression of multiple NBPF genes.Scientific reports · 2021Article
- Protective effects of miR-155-5p silencing on IFN-γ-induced apoptosis and inflammation in salivary gland epithelial cells.Experimental and therapeutic medicine · 2021Article
- Diverse Molecular Mechanisms Contribute to Differential Expression of Human Duplicated Genes.Molecular biology and evolution · 2021Article
- Analysis of conserved miRNAs in cynomolgus macaque genome using small RNA sequencing and homology searching.PeerJ · 2020Article
- Plasma MicroRNA Expression Profiles in Psoriasis.Journal of immunology research · 2020Article
- Potential Implications of Long Noncoding RNAs in Autoimmune Diseases.Immune network · 2019Review
- Upregulation of miR-221/222 expression in rheumatoid arthritis (RA) patients: correlation with disease activity.Clinical and experimental medicine · 2019Article
- Article
- MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment.Molecular diagnosis & therapy · 2017Review
- Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis.Cell research · 2017Article
- Article
- Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sjögren syndrome.Immunologic research · 2016Article
- MicroRNAs Regulating Signaling Pathways: Potential Biomarkers in Systemic Sclerosis.Genomics, proteomics & bioinformatics · 2015Review
- Intravenous immunoglobulins (IVIG) in systemic sclerosis: a challenging yet promising future.Immunologic research · 2015Review
- Molecular mechanisms in autoimmune type 1 diabetes: a critical review.Clinical reviews in allergy & immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The etiology and pathogenesis of human autoimmune diseases remain unknown despite intensive investigations. Although remarkable progress has been accomplished through genome wide association studies in the identification of genetic factors that may predispose to their occurrence or modify their clinical presentation to date no specific gene abnormalities have been conclusively demonstrated to be responsible for these diseases. The completion of the human and chimpanzee genome sequencing has opened up novel opportunities to examine the possible contribution of human specific genes and other regulatory elements unique to the human genome, such as microRNAs and non-coding RNAs, towards the pathogenesis of a variety of human disorders. Thus, it is likely that these human specific genes and non-coding regulatory elements may be involved in the development or the pathogenesis of various disorders that do not occur in non-human primates including certain autoimmune diseases such as Systemic Sclerosis and Primary Sjögren's Syndrome. Here, we discuss recent evidence supporting the notion that human specific genes or human specific microRNA and other non-coding RNA regulatory elements unique to the human genome may participate in the development or in the pathogenesis of Systemic Sclerosis and Primary Sjögren's Syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.