ArticleAnnals of family medicine
Association of depression with increased risk of severe hypoglycemic episodes in patients with diabetes.
Article in Annals of family medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Depression and unplanned secondary healthcare use in patients with multimorbidity: A systematic review.PloS one · 2022Pooled it
- Does anxiety predict the use of urgent care by people with long term conditions? A systematic review with meta-analysis.Journal of psychosomatic research · 2014Pooled it
- Selected factors determining a way of coping with stress in type 2 diabetic patients.BioMed research international · 2014Trial
- Association between vitamin D levels and depression among type 2 diabetes mellitus patients in the Southern Region of Malaysia.The Pan African medical journal · 2026Article
- Feasibility and acceptability of a two-phase survey for estimating the prevalence of mental disorders in adults with type 1 diabetes.Pilot and feasibility studies · 2025Article
- Individualized treatment of diabetes mellitus in older adults.Geriatrics & gerontology international · 2024Review
- The effect of educational intervention based on social support theory on the perceived stress caused by the covid-19 pandemic in patients with diabetes in hormozgan (2020-2021).BMC public health · 2024Article
- Relationships of hypoglycemia awareness, hypoglycemia beliefs, and continuous glucose monitoring glycemic profiles with anxiety and depression symptoms in adults with type 1 diabetes using continuous glucose monitoring systems.Diabetes research and clinical practice · 2024Article
- Effects of Diabetes Mellitus-Related Dysglycemia on the Functions of Blood-Brain Barrier and the Risk of Dementia.International journal of molecular sciences · 2023Review
- Persistence of Depressive Symptoms and Risk of Incident Cardiovascular Disease With and Without Diabetes: Results from the REGARDS Study.Journal of general internal medicine · 2022Article
- Epidemiology and risk factors of hypoglycemia in subjects with type 1 diabetes in Brazil: a cross-sectional, multicenter study.Archives of endocrinology and metabolism · 2022Article
- Spiritual intelligence, mindfulness, emotional dysregulation, depression relationship with mental well-being among persons with diabetes during COVID-19 pandemic.Journal of diabetes and metabolic disorders · 2021Article
- Identifying patients at increased risk of hypoglycaemia in primary care: Development of a machine learning-based screening tool.Diabetes/metabolism research and reviews · 2021Article
- Increased Risk of Cardiovascular Disease and Mortality in Patients with Diabetes and Coexisting Depression: A Nationwide Population-Based Cohort Study.Diabetes & metabolism journal · 2021Article
- Are depressive symptoms associated with quality of care in diabetes? Findings from a nationwide population-based study.BMJ open diabetes research & care · 2021Article
- Depression Among Patients with Type 2 Diabetes Mellitus: Prevalence and Associated Factors in Hue City, Vietnam.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Differences in the cluster of depressive symptoms between subjects with type 2 diabetes and individuals with a major depressive disorder and without diabetes.Journal of endocrinological investigation · 2019Article
- Hypoglycaemic treatment adherence and the association with psychological, self-management and glycaemic characteristics in adults with type 1 diabetes.Nursing open · 2019Article
- Article
- Risk Factors for Hypoglycemic Coma: A Study of 33 Patients on Insulin Therapy Who Were Transported to the Hospital by Ambulance.Internal medicine (Tokyo, Japan) · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
purposeAlthough psychosocial and clinical factors have been found to be associated with hypoglycemic episodes in patients with diabetes, few studies have examined the association of depression with severe hypoglycemic episodes. This study examined the prospective association of depression with risk of hypoglycemic episodes requiring either an emergency department visit or hospitalization.
methodsIn a longitudinal cohort study, a sample of 4,117 patients with diabetes enrolled between 2000 and 2002 were observed from 2005 to 2007. Meeting major depression criteria on the Patient Health Questionnaire-9 was the exposure of interest, and the outcome of interest was an International Classification of Disease, Ninth Revision code for a hypoglycemic episode requiring an emergency department visit or hospitalization. Proportional hazard models were used to analyze the association of baseline depression and risk of one or more severe hypoglycemic episodes. Poisson regression was used to determine whether depression status was associated with the number of hypoglycemic episodes.
resultsAfter adjusting for sociodemographic, clinical measures of diabetes severity, non-diabetes-related medical comorbidity, prior hypoglycemic episodes, and health risk behaviors, depressed compared with nondepressed patients who had diabetes had a significantly higher risk of a severe hypoglycemic episode (hazard ratio = 1.42, 95% CI, 1.03-1.96) and a greater number of hypoglycemic episodes (odds ratio = 1.34, 95% CI, 1.03-1.74).
conclusionDepression was significantly associated with time to first severe hypoglycemic episode and number of hypoglycemic episodes. Research assessing whether recognition and effective treatment of depression among persons with diabetes prevents severe hypoglycemic episodes is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.