ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2013
A composite risk model for predicting technical failure in pancreas transplantation.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk indices predicting graft use, graft and patient survival in solid pancreas transplantation: a systematic review.BMC gastroenterology · 2021Pooled it
- Expanding the Pancreas Donor Pool: Reassessing the Impact of Donor Body Mass Index on Transplant Outcomes.Clinical transplantation · 2026Article
- The Time-varying Impact of Pancreas Graft Failure on Mortality and Kidney Graft Outcomes in Simultaneous Pancreas and Kidney Transplantation.Transplantation direct · 2026Article
- Neddylation blockade protects endothelial cells against inflammation and ischemia-reperfusion injuries.Cell communication and signaling : CCS · 2026Article
- Anti-TNFα as an Adjunctive Therapy in Pancreas and Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Outcome-Orientated Organ Allocation-A Composite Risk Model for Pancreas Graft Evaluation and Acceptance.Journal of clinical medicine · 2024Article
- Dueling with the dual artery blood supply in pancreas transplantation: why replace the Y?Gland surgery · 2024Article
- Does Timepoint of Surgical Procedure Affect the Outcome in Simultaneous Pancreas-Kidney Transplantation? A Retrospective Single-Center Analysis over 20 Years.Journal of clinical medicine · 2024Article
- Donor noradrenaline use is associated with better allograft survival in recipients of pancreas transplantation.Annals of the Royal College of Surgeons of England · 2024Article
- Survival Benefit of Solid-Organ Transplantation: 10-Year Update.Digestive diseases and sciences · 2023Article
- Sterile Pancreas Inflammation during Preservation and after Transplantation.International journal of molecular sciences · 2023Review
- Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Modification of Venous Outflow to Avoid Thrombotic Graft Failure in Pancreas Transplantation.Annals of transplantation · 2022Article
- Improved surgical outcomes following simultaneous pancreas-kidney transplantation in the contemporary era.Clinical transplantation · 2022Article
- Transplant Options for Patients With Diabetes and Advanced Kidney Disease: A Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Review
- Donor insulin therapy in intensive care predicts early outcomes after pancreas transplantation.Diabetologia · 2021Article
- The Value of Graft Implantation Sequence in Simultaneous Pancreas-Kidney Transplantation on the Outcome and Graft Survival.Journal of clinical medicine · 2021Article
- Recipient age and outcome after pancreas transplantation: a retrospective dual-center analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2021Article
- Early detection of complications in pancreas transplants by microdialysis catheters, an observational feasibility study.PloS one · 2021Observational
- Immediate post-operative complications (I): Post-operative bleeding; vascular origin: Thrombosis pancreatitis.World journal of transplantation · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Technical failure (TF) continues to have a significant impact on the success of pancreas transplantation. We assessed risk factors for TF in 1115 pancreas transplants performed at a single center between 1998 and 2011. The overall TF rate was 10.2%. In a multivariable model, donor BMI ≥ 30 (HR 1.87, p = 0.005), donor Cr ≥ 2.5 (HR 3.16, p = 0.007), donor age >50 (HR 1.73, p = 0.082) and preservation time >20 h (HR 2.17, p < 0.001) were associated with TF. Bladder drainage of exocrine secretions was protective (HR 0.54, p = 0.002). We incorporated these factors in a Composite Risk Model. In this model the presence of one risk factor did not significantly increase risk of TF (HR 1.35, p = 0.346). Two risk factors in combination increased risk greater than threefold (HR 3.65, p < 0.001) and three risk factors increased risk greater than sevenfold (HR 7.66, p = <0.001). The analysis also identified many factors that were not predictive of TF, including previous transplants, immunosuppressive agent selection, and almost all recipient demographic parameters. While the model suggests that two or more risk factors predict TF, strategies to reduce preservation time may mitigate some of this risk.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.