ArticlePLoS pathogens2013
Increase in gut microbiota after immune suppression in baculovirus-infected larvae.
Article in PLoS pathogens, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 91 citations in OpenAlex.
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- Microbiome-Epigenome Interplay Impacts Microbial Symbiosis and Stress Adaptations in the Brown Planthopper (International journal of molecular sciences · 2026Article
- Immune Response and Gut Microbiota Shift in the Red Palm Weevil (Rhynchophorus ferrugineus) Infected With Entomopathogenic Fungus, Beauveria bassiana, Reveal Host-Pathogen Interactions.Archives of insect biochemistry and physiology · 2026Article
- Disentangling the Role of Microbiota: A Special Emphasis on Lepidoptera.Current microbiology · 2026Review
- Invertebrate Iridescent Viruses (Viruses · 2025Article
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- Towards a Rational Basis for the Selection of Probiotics to Improve Silkworm Health and Performance.Insects · 2025Review
- Metagenomic Analyses Reveal Gut Microbial Profiles ofMicroorganisms · 2024Article
- MicroRNA-Mediated Host Immune Genes Manipulation Benefits AcMNPV Proliferation inJournal of agricultural and food chemistry · 2023Article
- Feeding Spodoptera exigua larvae with gut-derived Escherichia sp. increases larval juvenile hormone levels inhibiting cannibalism.Communications biology · 2023Article
- Symbiotic Bacteria ModulateInternational journal of molecular sciences · 2023Article
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- Compatibility of mycorrhiza-induced resistance with viral and bacterial entomopathogens in the control of Spodoptera exigua in tomato.Pest management science · 2022Article
- Diversity and Functional Roles of the Gut Microbiota in Lepidopteran Insects.Microorganisms · 2022Review
- Topical Fungal Infection Induces Shifts in the Gut Microbiota Structure of Brown Planthopper,Insects · 2022Article
- The gut microbiota composition of Trichoplusia ni is altered by diet and may influence its polyphagous behavior.Scientific reports · 2021Article
- Relative contributions of various endogenous and exogenous factors to the mosquito microbiota.Parasites & vectors · 2020Article
- The Tripartite Interaction of Host Immunity-Toxins · 2020Review
- Influence of Diet, Sex, and Viral Infections on the Gut Microbiota Composition ofFrontiers in microbiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spodoptera exigua microarray was used to determine genes differentially expressed in S. exigua cells challenged with the species-specific baculovirus SeMNPV as well as with a generalist baculovirus, AcMNPV. Microarray results revealed that, in contrast to the host transcriptional shut-off that is expected during baculovirus infection, S. exigua cells showed a balanced number of up- and down-regulated genes during the first 36 hours following the infection. Many immune-related genes, including pattern recognition proteins, genes involved in signalling and immune pathways as well as immune effectors and genes coding for proteins involved in the melanization cascade were found to be down-regulated after baculovirus infection. The down-regulation of immune-related genes was confirmed in the larval gut. The expression of immune-related genes in the gut is known to affect the status of gut microorganisms, many of which are responsible for growth and development functions. We therefore asked whether the down-regulation that occurs after baculovirus infection affects the amount of gut microbiota. An increase in the gut bacterial load was observed and we hypothesize this to be as a consequence of viral infection. Subsequent experiments on virus performance in the presence and absence of gut microbiota revealed that gut bacteria enhanced baculovirus virulence, pathogenicity and dispersion. We discuss the host immune response processes and pathways affected by baculoviruses, as well as the role of gut microbiota in viral infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.