ArticleMolecular biology of the cell2013
Retromer maintains basolateral distribution of the type II TGF-β receptor via the recycling endosome.
Article in Molecular biology of the cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Endosome traffic in rheumatic diseases: mechanistic insights and therapeutic opportunities.Nature reviews. Rheumatology · 2026Review
- TGFβ1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation.Respiratory research · 2023Article
- Myofibroblast specific targeting approaches to improve fibrosis treatment.Chemical communications (Cambridge, England) · 2022Review
- A juxtamembrane basolateral targeting motif regulates signaling through a TGF-β pathway receptor in Drosophila.PLoS biology · 2022Article
- Transforming growth factor-β in tumour development.Frontiers in molecular biosciences · 2022Review
- Depletion ofGenes & diseases · 2021Article
- TGF-β Signaling.Biomolecules · 2020Review
- Specificity, versatility, and control of TGF-β family signaling.Science signaling · 2019Review
- Article
- The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery.Cell reports · 2018Article
- This Is the End: Regulation of Rab7 Nucleotide Binding in Endolysosomal Trafficking and Autophagy.Frontiers in cell and developmental biology · 2018Review
- Basolateral delivery of the type I transforming growth factor beta receptor is mediated by a dominant-acting cytoplasmic motif.Molecular biology of the cell · 2017Article
- Membrane Transport across Polarized Epithelia.Cold Spring Harbor perspectives in biology · 2017Review
- Signaling Receptors for TGF-β Family Members.Cold Spring Harbor perspectives in biology · 2016Review
- Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth.Molecular biology of the cell · 2016Article
- Beclin 1 regulates neuronal transforming growth factor-β signaling by mediating recycling of the type I receptor ALK5.Molecular neurodegeneration · 2015Article
- Cell density sensing alters TGF-β signaling in a cell-type-specific manner, independent from Hippo pathway activation.Developmental cell · 2015Article
- BMP signaling requires retromer-dependent recycling of the type I receptor.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Adaptor proteins involved in polarized sorting.The Journal of cell biology · 2014Review
- A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis.Nature reviews. Cancer · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Transforming growth factor β (TGF-β) is critical for the development and maintenance of epithelial structures. Because receptor localization and trafficking affect the cellular and organismal response to TGF-β, the present study was designed to address how such homeostatic control is regulated. To that end, we identify a new role for the mammalian retromer complex in maintaining basolateral plasma membrane expression of the type II TGF-β receptor (TβRII). Retromer and TβRII associate in the presence or absence of TGF-β ligand. After retromer knockdown, although TβRII internalization and trafficking to a Rab5-positive compartment occur as in wild-type cells, receptor recycling is inhibited. This results in TβRII mislocalization from the basolateral to both the basolateral and apical plasma membranes independent of Golgi transit and the Rab11-positive apical recycling endosome. The data support a model in which, after initial basolateral TβRII delivery, steady-state polarized TβRII expression is maintained by retromer/TβRII binding and delivery to the common recycling endosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.