SynthesisClinical journal of the American Society of Nephrology : CJASN2013
Systematic review of structural and functional neuroimaging findings in children and adults with CKD.
Synthesis in Clinical journal of the American Society of Nephrology : CJASN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Systematic review of neuroimaging findings in children and young adults with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- Neurodevelopmental outcomes in children with chronic kidney disease: a scoping review.Pediatric nephrology (Berlin, Germany) · 2026Review
- Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- Crosstalk of kidney and brain in diabetes-related cognitive impairment and therapeutic strategies.Frontiers in endocrinology · 2025Review
- Neurodevelopmental profile of infants and toddlers awaiting a kidney transplant.Pediatric nephrology (Berlin, Germany) · 2024Article
- Blunted cerebral hemodynamic responses to incremental exercise in patients with end-stage renal disease.International urology and nephrology · 2024Article
- Association of cognitive impairment with the interaction between chronic kidney disease and depression: findings from NHANES 2011-2014.BMC psychiatry · 2024Article
- Understanding the impact of pediatric kidney transplantation on cognition: A review of the literature.Pediatric transplantation · 2023Review
- Risk factors for neurocognitive impairment and the relation with structural brain abnormality in children and young adults with severe chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- The kidney-brain pathogenic axis in severe falciparum malaria.Trends in parasitology · 2023Review
- Stroke Subtype Among Individuals With Chronic Kidney Disease.Canadian journal of kidney health and disease · 2023Article
- Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis.Kidney diseases (Basel, Switzerland) · 2022Review
- Structural brain abnormalities in children and young adults with severe chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2022Article
- Global and Regional White Matter Fractional Anisotropy in Children with Chronic Kidney Disease.The Journal of pediatrics · 2022Article
- Covert vascular brain injury in chronic kidney disease.Frontiers in neurology · 2022Review
- Impact of Chronic Kidney Disease on Brain Structure and Function.Frontiers in neurology · 2022Review
- Functional Magnetic Resonance Imaging Findings in Children and Adolescents With Chronic Kidney Disease: Preliminary Findings.Seminars in nephrology · 2021Review
- Cognitive Dysfunction and Gait Abnormalities in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2021Article
- Intradialytic hypotension and relationship with cognitive function and brain morphometry.Clinical kidney journal · 2021Article
- The Similarities and Differences Between Glomerular vs. Non-glomerular Diagnoses on Intelligence and Executive Functions in Pediatric Chronic Kidney Disease: A Brief Report.Frontiers in neurology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
CKD has been linked with cognitive deficits and affective disorders in multiple studies. Analysis of structural and functional neuroimaging in adults and children with kidney disease may provide additional important insights into the pathobiology of this relationship. This paper comprehensively reviews neuroimaging studies in both children and adults. Major databases (PsychLit, MEDLINE, WorldCat, ArticleFirst, PubMed, Ovid MEDLINE) were searched using consistent search terms, and studies published between 1975 and 2012 were included if their samples focused on CKD as the primary disease process. Exclusion criteria included case reports, chapters, and review articles. This systematic process yielded 43 studies for inclusion (30 in adults, 13 in children). Findings from this review identified several clear trends: (1) presence of cerebral atrophy and cerebral density changes in patients with CKD; (2) cerebral vascular disease, including deep white matter hyperintensities, white matter lesions, cerebral microbleeds, silent cerebral infarction, and cortical infarction, in patients with CKD; and (3) similarities in regional cerebral blood flow between patients with CKD and those with affective disorders. These findings document the importance of neuroimaging procedures in understanding the effect of CKD on brain structure, function, and associated behaviors. Results provide a developmental linkage between childhood and adulthood, with respect to the effect of CKD on brain functioning across the lifespan, with strong implications for a cerebrovascular mechanism contributing to this developmental linkage. Use of neuroimaging methods to corroborate manifest neuropsychological deficits or perhaps to indicate preventive actions may prove useful to individuals with CKD.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.