ReviewBioMed research international2013
Oxidation of marine omega-3 supplements and human health.
Review in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed.
- Fish oil blunts lung function decrements induced by acute exposure to ozone in young healthy adults: A randomized trial.Environment international · 2022Trial
- Statin dose reduction with complementary diet therapy: A pilot study of personalized medicine.Molecular metabolism · 2018Trial
- Lipidomic changes of LDL in overweight and moderately hypercholesterolemic subjects taking phytosterol- and omega-3-supplemented milk.Journal of lipid research · 2015Trial
- Non-Pharmacological Strategies in Atherosclerotic Cardiovascular Disease: From Molecular Mechanisms to Clinical Integration.Biomedicines · 2026Review
- Is Higher α-Linolenic Acid Content Preferable? Assessing Digestive Fate of Flaxseed Oil inFoods (Basel, Switzerland) · 2026Article
- A Framework for Developing Intake and Use Guidance for Dietary Supplement Bioactives.Advances in nutrition (Bethesda, Md.) · 2026Review
- Association between circulating ω-3 polyunsaturated fatty acid levels and left cardiac myocardial strain in hypertension: a CMR-FT study.Frontiers in nutrition · 2026Article
- Article
- Structural Insights and Biological Activities of Furan-Based Drugs in the Treatment of Human Diseases.Combinatorial chemistry & high throughput screening · 2025Review
- Comparative Analysis of Fatty Acid Bioaccessibility in Commercial Marine Oil Supplements: An In Vitro Integrated Analytical Study.Foods (Basel, Switzerland) · 2024Article
- Functional Breads with Encapsulated Vitamin C and Fish Oil: Nutritional, Technological, and Sensory Attributes.Antioxidants (Basel, Switzerland) · 2024Article
- Omega-3 Polyunsaturated Fatty Acids in Depression.International journal of molecular sciences · 2024Review
- Omega-3 fatty acids and major depression: a Mendelian randomization study.Translational psychiatry · 2024Article
- Composition and fatty acid profile of milk from cows fed diets supplemented with raw and n-3 PUFA-enriched fish oil.Scientific reports · 2024Article
- Evaluation of the Metabolite Profile of Fish Oil Omega-3 Fatty Acids (n-3 FAs) in Micellar and Enteric-Coated Forms-A Randomized, Cross-Over Human Study.Metabolites · 2024Article
- Insights Into Inflammatory Bowel Disease and Effects of Dietary Fatty Acid Intake With a Focus on Polyunsaturated Fatty Acids Using Preclinical Models.Journal of the Canadian Association of Gastroenterology · 2024Review
- The role of polyunsaturated fatty acids in the neurobiology of major depressive disorder and suicide risk.Molecular psychiatry · 2024Review
- n-3 PUFA ameliorate functional outcomes following repetitive mTBI in theFrontiers in nutrition · 2024Article
- Effects of Controlled Ozone Exposure on Circulating microRNAs and Vascular and Coagulation Biomarkers: A Mediation Analysis.Non-coding RNA · 2023Article
- Dietary pro-oxidant score (POS) and cardio-metabolic panel among obese individuals: a cross-sectional study.BMC endocrine disorders · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine omega-3 rich oils are used by more than a third of American adults for a wide range of purported benefits including prevention of cardiovascular disease. These oils are highly prone to oxidation to lipid peroxides and other secondary oxidation products. Oxidized oils may have altered biological activity making them ineffective or harmful, though there is also evidence that some beneficial effects of marine oils could be mediated through lipid peroxides. To date, human clinical trials have not reported the oxidative status of the trial oil. This makes it impossible to understand the importance of oxidation to efficacy or harm. However, animal studies show that oxidized lipid products can cause harm. Oxidation of trial oils may be responsible for the conflicting omega-3 trial literature, including the prevention of cardiovascular disease. The oxidative state of an oil can be simply determined by the peroxide value and anisidine value assays. We recommend that all clinical trials investigating omega-3 harms or benefits report the results of these assays; this will enable better understanding of the benefits and harms of omega-3 and the clinical importance of oxidized supplements.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.