ArticleDevelopment (Cambridge, England)2013
Polycomb repressive complex PRC2 regulates Xenopus retina development downstream of Wnt/β-catenin signaling.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Ezh2 Control of Bivalent Genes Fine-Tunes Developmental Competence During Retinogenesis.Investigative ophthalmology & visual science · 2026Article
- Disruption of common ocular developmental pathways in patient-derived optic vesicle models of microphthalmia.Stem cell reports · 2024Article
- Advances in the study of Müller glia reprogramming in mammals.Frontiers in cellular neuroscience · 2023Review
- Review
- Transcriptional and epigenetic regulation of temporal patterning in neural progenitors.Developmental biology · 2022Review
- Transcriptomics-Based Repositioning of Natural Compound, Eudesmin, as a PRC2 Modulator.Molecules (Basel, Switzerland) · 2021Article
- Epigenetic regulation of retinal development.Epigenetics & chromatin · 2021Review
- Building a Mammalian Retina: An Eye on Chromatin Structure.Frontiers in genetics · 2021Review
- Reprogramming Müller Glia to Regenerate Retinal Neurons.Annual review of vision science · 2020Review
- DNA demethylation is a driver for chick retina regeneration.Epigenetics · 2020Article
- Jmjd3 Plays Pivotal Roles in the Proper Development of Early-Born Retinal Lineages: Amacrine, Horizontal, and Retinal Ganglion Cells.Investigative ophthalmology & visual science · 2020Article
- The regulatory proteins DSCR6 and Ezh2 oppositely regulate Stat3 transcriptional activity in mesoderm patterning duringThe Journal of biological chemistry · 2020Article
- Genetic and epigenetic control of retinal development in zebrafish.Current opinion in neurobiology · 2019Review
- Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo.Stem cell reports · 2019Article
- Article
- Small Molecule GSK-J1 Affects Differentiation of Specific Neuronal Subtypes in Developing Rat Retina.Molecular neurobiology · 2019Article
- Article
- Fibroblast growth factor receptor 1 signaling transcriptionally regulates the axon guidance cue slit1.Cellular and molecular life sciences : CMLS · 2018Article
- Epigenetic control of gene regulation during development and disease: A view from the retina.Progress in retinal and eye research · 2018Review
- Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The histone methyltransferase complex PRC2 controls key steps in developmental transitions and cell fate choices; however, its roles in vertebrate eye development remain unknown. Here, we report that in Xenopus, PRC2 regulates the progression of retinal progenitors from proliferation to differentiation. We show that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation, in part due to upregulation of the Cdk inhibitor p15(Ink4b). In addition, although PRC2 knockdown does not alter eye patterning, retinal progenitor gene expression or expression of the neural competence factor Sox2, it does cause suppression of proneural bHLH gene expression, indicating that PRC2 is crucial for the initiation of neural differentiation in the retina. Consistent with this, knocking down or blocking PRC2 function constrains the generation of most retinal neural cell types and promotes a Müller glial cell fate decision. We also show that Wnt/β-catenin signaling acting through the receptor Frizzled 5, but independent of Sox2, regulates expression of key PRC2 subunits in the developing retina. This is consistent with a role for this pathway in coordinating proliferation and the transition to neurogenesis in the Xenopus retina. Our data establish PRC2 as a regulator of proliferation and differentiation during eye development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.