Evidence map›Paper›PMID 23744715›Full record

ReviewJournal of biomedical materials research. Part B, Applied biomaterials2013

Topographical control of ocular cell types for tissue engineering.

Kevin J McHugh, Magali Saint-Geniez, Sarah L Tao

Open access · greenAbstract readReview
In one paragraph

Review in Journal of biomedical materials research. Part B, Applied biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Kevin J McHughThe Charles Stark Draper Laboratory, Cambridge, Massachusetts; Schepens Eye Research Institute, Boston, Massachusetts; Department of Biomedical Engineering, Boston University, Boston, Massachusetts.
Magali Saint-Geniez
Sarah L Tao
Draper Laboratory · USHarvard University · USSmith-Kettlewell Eye Research Institute · US

Funding

Translational Research in BiomaterialsT32EB006359 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MARK W. GRINSTAFF, Michelle H Teplensky · 2009 to 2026
$4.2M
Bioengineering of Bruch's Membrane for the treatment of Age-related Macular DegenDP2OD006649 · OD · SCHEPENS EYE RESEARCH INSTITUTE · PI SAINT-GENIEZ, MAGALI · 2009 to 2009
$2.9M
NIBIB NIH HHS T32 EB006359NIH HHS DP2 OD006649
6 · The paper itself

Abstract

Visual impairment affects over 285 million people worldwide and has a major impact on an individual's quality of life. Tissue engineering has the potential to increase the quality of life for many of these patients by preventing vision loss or restoring vision using cell-based therapies. However, these strategies will require an understanding of the microenvironmental factors that influence cell behavior. The eye is a well-organized organ whose structural complexity is essential for proper function. Interactions between ocular cells and their highly ordered extracellular matrix are necessary for maintaining key tissue properties including corneal transparency and retinal lamination. Therefore, it is not surprising that culturing these cells in vitro on traditional flat substrates result in irregular morphology. Instead, topographically patterned biomaterials better mimic native extracellular matrix and have been shown to elicit in vivo-like morphology and gene expression which is essential for tissue engineering. Herein we review multiple methods for producing well-controlled topography and discuss optimal biomaterial scaffold design for cells of the cornea, retina, and lens.

Indexed as

Biocompatible MaterialsCorneaExtracellular MatrixEyeHumansLasersLens, CrystallineNanostructuresOphthalmologic Surgical ProceduresQuality of LifeRetinaSurface PropertiesTissue EngineeringBiocompatible Materialscell-material interactionseyemicrostructurenanomaterials/nanophaseophthalmic

Identifiers

PMID23744715
PMCPMC4090092
OpenAlexW2097846647

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.