Evidence map›Paper›PMID 23748227›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014

Small-volume analysis of cell-cell signaling molecules in the brain.

Elena V Romanova, Jordan T Aerts, Callie A Croushore, Jonathan V Sweedler

Abstract readReview
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Peptidomics.Nature reviews. Methods primers · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  11. 'Full fusion' is not ineluctable during vesicular exocytosis of neurotransmitters by endocrine cells.Proceedings. Mathematical, physical, and engineering sciences · 2017
    Article
  12. Article
  13. Article
  14. Peptidomics and Secretomics of the Mammalian Peripheral Sensory-Motor System.Journal of the American Society for Mass Spectrometry · 2015
    Article
  15. Lutein and Brain Function.Foods (Basel, Switzerland) · 2015
    Article
  16. Review
  17. Article
  18. Review
  19. Advances in Mass Spectrometric Tools for Probing Neuropeptides.Annual review of analytical chemistry (Palo Alto, Calif.) · 2015
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elena V RomanovaBeckman Institute for Advanced Science and Technology and the Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Jordan T Aerts
Callie A Croushore
Jonathan V Sweedler

Funding

The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Jonathan V. Sweedler · 2004 to 2026
$24.9M
SUBCELLULAR CHARACTERIZATION OF NEUROTRANSMITTERSR01NS031609 · NINDS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI SWEEDLER, JONATHAN V. · 1998 to 2022
$6.2M
NEUROTRANSMITTER RELEASER29NS031609 · NINDS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI SWEEDLER, JONATHAN V. · 1993 to 1997
–
NIDA NIH HHS P30 DA018310NINDS NIH HHS NS031609NINDS NIH HHS R01 NS031609
6 · The paper itself

Abstract

Modern science is characterized by integration and synergy between research fields. Accordingly, as technological advances allow new and more ambitious quests in scientific inquiry, numerous analytical and engineering techniques have become useful tools in biological research. The focus of this review is on cutting edge technologies that aid direct measurement of bioactive compounds in the nervous system to facilitate fundamental research, diagnostics, and drug discovery. We discuss challenges associated with measurement of cell-to-cell signaling molecules in the nervous system, and advocate for a decrease of sample volumes to the nanoliter volume regimen for improved analysis outcomes. We highlight effective approaches for the collection, separation, and detection of such small-volume samples, present strategies for targeted and discovery-oriented research, and describe the required technology advances that will empower future translational science.

Indexed as

Brain ChemistryCell CommunicationSignal TransductionAnimalsFunctional NeuroimagingHumansMass SpectrometryMicrochemistryTissue Array Analysis

Identifiers

PMID23748227
PMCPMC3857641

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.