Trial reportDiabetes care2013
A single session of low-intensity exercise is sufficient to enhance insulin sensitivity into the next day in obese adults.
Trial report in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03894527 (Impact of Acute Exercise on Vascular Insulin Sensitivity in Metabolic Syndrome), which is not on this map. Cited by 60 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Acute Exercise on Vascular Insulin Sensitivity in Metabolic Syndrome
Who cites it
60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Physical exercise as treatment for adults with type 2 diabetes: a rapid review.Frontiers in endocrinology · 2023Pooled it
- Effect of continuous aerobic exercise on endothelial function: A systematic review and meta-analysis of randomized controlled trials.Frontiers in physiology · 2023Pooled it
- Pooled it
- How does light-intensity physical activity associate with adult cardiometabolic health and mortality? Systematic review with meta-analysis of experimental and observational studies.British journal of sports medicine · 2019Pooled it
- Fasting-induced glucose intolerance is not impacted by the addition of daily exercise: A randomized crossover study.The Journal of physiology · 2026Trial
- Acute impairments in glucose tolerance following one night of partial sleep restriction are not rescued by moderate-intensity walking in young men.European journal of applied physiology · 2026Trial
- Successfully Reducing Sitting Time Can Improve Metabolic Flexibility.Scandinavian journal of medicine & science in sports · 2025Trial
- The effect of periodic resistance training on obese patients with type 2 diabetic nephropathy.Scientific reports · 2024Trial
- Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults.The Journal of clinical endocrinology and metabolism · 2020Trial
- Energy Deficit Required for Exercise-induced Improvements in Glycemia the Next Day.Medicine and science in sports and exercise · 2020Trial
- Consecutive days of exercise decrease insulin response more than a single exercise session in healthy, inactive men.European journal of applied physiology · 2019Trial
- Trial
- Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans.Diabetologia · 2016Trial
- Trial
- Effect of acute postprandial exercise on continuous glucose monitoring outcomes in type 2 diabetes: A systematic review and meta-analysis of crossover trials.Reviews in endocrine & metabolic disorders · 2026Review
- Nutritional considerations for athletes with diabetes: optimizing performance and glycemic control.Frontiers in nutrition · 2026Review
- The Role of Exercise in Cardiovascular Metabolism and Its Importance for Adolescent Metabolic Health.Advances in experimental medicine and biology · 2026Review
- Effects of Red Wine and Daily Exercise on Glycemic Control in Insulin Resistant Individuals.International journal of exercise science · 2026Article
- Lipidomic markers of habitual physical activity and risk of type 2 diabetes in American Indians.Scientific reports · 2025Article
- Weightlifting outperforms voluntary wheel running for improving adiposity and insulin sensitivity in obese mice.Journal of sport and health science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe purpose of this study was to determine the effect of a relatively modest session of exercise on insulin sensitivity and fatty acid uptake the next day in obese adults. RESEARCH DESIGN AND
methodsEleven sedentary obese adults (male/female: 3/8; BMI 37 ± 1 kg/m(2); peak oxygen uptake [VO2peak] 20 ± 1 mL/kg/min) completed three experimental trials. On two of these occasions, subjects exercised to expend 350 kcal in the afternoon. These two exercise trials were identical except for the exercise intensity (50% VO2peak [EX50] and 65% VO2peak [EX65]) and the duration of exercise necessary to expend 350 kcal (EX50 = ≈ 70 min; EX65 = ≈ 55 min). Subjects also completed a control trial (CON), without exercise. The next morning, we measured insulin sensitivity (hyperinsulinemic-euglycemic clamp) and whole-body fatty acid uptake (palmitate rate of disappearance from plasma [Rd]).
resultsExercise increased insulin sensitivity the next day, but whereas the 35% improvement after EX50 compared with CON was statistically significant (P = 0.01), the 20% improvement after EX65 was not (P = 0.17). Despite nearly identical values between CON and EX65 (P = 0.88), systemic fatty acid uptake was lower after EX50 compared with EX65 (P = 0.02), but not quite significant compared with CON (P = 0.07). Importantly, the change in fatty acid uptake after exercise compared with CON was negatively correlated with the change in insulin sensitivity for all trials (r = -0.60, P = 0.003).
conclusionsA relatively modest single session of exercise in obese adults improved insulin sensitivity the next day, and a reduction in systemic fatty acid uptake in the several hours after exercise may be important for this effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.