ArticlePloS one2013
Age- and sex-based hematological and biochemical parameters for Macaca fascicularis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 80 citations in OpenAlex.
- Hematology and Serum Biochemistry Reference Intervals for Captive-Born Owl Monkeys (Aotus nancymae): Effects of Age and Sex.Journal of medical primatology · 2026Article
- Age- and sex- related patterns in hematobiochemical and anthropometric parameters of Macaca monkeys.GeroScience · 2026Article
- A Cross-Sectional Evaluation of Cardiovascular and Metabolic Functions During Aging and Pregnancy in the Cynomolgus Monkey.Journal of medical primatology · 2025Article
- 13-Month Follow Up of Acclimation of Cynomolgus Macaques (Macaca fascicularis) on Haematology, Serum Biochemistry, and Body Weight Changes.Journal of medical primatology · 2025Article
- Biochemical and hematological reference intervals in rhesus and cynomolgus macaques and implications for vaccine and drug development.Lab animal · 2025Article
- An Evaluation of the Safety of Intravenous Injections of the Natural Extracellular Hemoglobin M101 in Dogs and Monkeys.International journal of molecular sciences · 2025Article
- Age-associated alterations in immune and inflammatory responses in captive olive baboons (Frontiers in aging · 2024Article
- Determination of hematological and biochemical values blood parameters for European bison (Bison bonasus).PloS one · 2024Article
- Molecular Markers of Blood Cell Populations Can Help Estimate Aging of the Immune System.International journal of molecular sciences · 2023Review
- Prevalence and Characteristics of Myopia in Adult Non-Human Primates in Southwest China.Translational vision science & technology · 2023Article
- Reference Intervals and Percentiles for Hematologic and Serum Biochemical Values in Captive Bred Rhesus (Animals : an open access journal from MDPI · 2023Article
- Age-Related Changes in the Clustering of Blood Populations in Cynomolgus Monkeys Depend on Sex and Immune Status.Life (Basel, Switzerland) · 2023Article
- Pharmacokinetics of cannabidiol-/cannabidiolic acid-rich hemp oil in juvenile cynomolgus macaques (Frontiers in veterinary science · 2023Article
- Hematological and biochemical reference intervals of wild-caught and inhouse adult Indian rhesus macaques (Macaca mulatta).Laboratory animal research · 2022Article
- Age- and sex-related changes in body weights and clinical pathology analytes in cynomolgus monkeys (Macaca Fascicularis) of Mauritius origin.Veterinary clinical pathology · 2022Article
- Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors.Science advances · 2022Article
- Naturally Occurring Endocrine Disorders in Non-Human Primates: A Comprehensive Review.Animals : an open access journal from MDPI · 2022Review
- Seasonal Variability of Biochemical Parameters in Female Cynomolgus Macaques (Macaca fascicularis).Bulletin of experimental biology and medicine · 2022Article
- Retrospective Evaluation of a Minor Dietary Change in Non-Diabetic Group-Housed Long-Tailed Macaques (Animals : an open access journal from MDPI · 2021Article
- A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters.Science translational medicine · 2021Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cynomolgus monkey (Macaca fascicularis) has been increasingly used in biomedical research, making knowledge of its blood-based parameters essential to support the selection of healthy subjects and its use in preclinical research. As age and sex affect these blood-based parameters, it is important to establish baseline indices for these parameters on an age and sex basis and determine the effects of age and sex on these indices.
methodsA total of 917 cynomolgus monkeys (374 males and 543 females) were selected and segregated by age (five groups) and sex. A total of 30 hematological and 22 biochemical parameters were measured, and the effects of age and sex were analyzed.
resultsBaseline indices for hematological and biochemical parameters were separately established by age and sex. Significant effects by age, sex, and age-sex interaction were observed in a number of blood parameters. In the 49-60 months and 61-72 months age groups, red blood cell count, hemoglobulin, and hematocrit showed significantly lower values (P<0.01) in females than males. Serum alkaline phosphatase varied with age in both sexes (P<0.01) and was significantly higher in females than males (P<0.05) in the groups aged 13-24 months and 25-36 months; however, in the three groups aged over 25-36 months, serum alkaline phosphatase was significantly lower in females than males (P<0.01). Creatinine concentration increased with age (P<0.01) in all age groups; specifically in the groups aged 49-60 months and 61-72 months, creatinine was significantly higher (P<0.01) in males than females. Total protein and globulin both increased with age (P<0.01).
conclusionThe baseline values of hematological and biochemical parameters reported herein establish reference indices of blood-based parameters in the cynomolgus monkey by age and sex, thereby aiding researchers in selecting healthy subjects and evaluating preclinical studies using this species.
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