Evidence map›Paper›PMID 23770320›Full record

SynthesisThe Journal of steroid biochemistry and molecular biology2014

Cognition and mood in perimenopause: a systematic review and meta-analysis.

Miriam T Weber, Pauline M Maki, Michael P McDermott

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of steroid biochemistry and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  10. Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis.Climacteric : the journal of the International Menopause Society · 2015
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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Miriam T WeberDepartment of Neurology, University of Rochester, Box 673, 601 Elmwood Avenue, Rochester, NY 14642, United States. Electronic address: miriam_weber@urmc.rochester.edu.
Pauline M MakiDepartment of Psychiatry, University of Illinois at Chicago, 912 South Wood Street, Chicago, IL 60612, United States; Department of Psychology, University of Illinois at Chicago, 912 South Wood Street, Chicago, IL 60612, United States. Electronic address: pmaki@psych.uic.edu.
Michael P McDermottDepartment of Neurology, University of Rochester, Box 673, 601 Elmwood Avenue, Rochester, NY 14642, United States; Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Box 630, Rochester, NY 14642, United States. Electronic address: mikem@bst.rochester.edu.

Funding

NCATS NIH HHS UL1 TR000042NCRR NIH HHS UL1 RR024160NIA NIH HHS K23 AG034256NIA NIH HHS K23-AG54385484
6 · The paper itself

Abstract

objectiveIt is suggested that declines in estrogen around menopause are associated with declines in cognitive functioning as well as increased risk of depressive symptoms and depressive disorders. Existing studies of objective cognitive function and mood have differed in the criteria used to stage the menopausal transition and in the outcome measures used. The purpose of this review was to synthesize the existing studies of the relationship between menopausal stage and neuropsychological performance and depression.

designA search of the literature of observational studies was performed using PubMed. Four cross-sectional studies on menopausal transition stage and cognitive function and four longitudinal studies on menopausal transition stage and risk of depression, as measured by symptom inventories and structured clinical interviews, were selected. For the cognitive outcomes, fixed effects models were used to estimate overall standardized effect sizes. For the depression outcomes, the results of group comparisons were summarized using the log odds ratio and its estimated standard error.

resultsPostmenopausal women performed significantly worse than pre- and perimenopausal women on delayed verbal memory tasks, and significantly worse than perimenopausal women on phonemic verbal fluency tasks. Peri- and postmenopausal women were at significantly increased risk of depression, as measured by standard symptom inventories and structured clinical interviews, than premenopausal women.

conclusionsThe menopausal transition is a time of increased vulnerability to cognitive declines and increased risk of depressive symptoms and depressive disorders. However, these results cannot necessarily be generalized beyond the studies included in this review. This article is part of a Special Issue entitled 'Menopause'.

Indexed as

CognitionCross-Sectional StudiesDepressionFemaleHumansLongitudinal StudiesMemoryObservational Studies as TopicPerimenopausePremenopauseCognitionDepressionMemoryMenopausal transitionPerimenopause

Identifiers

PMID23770320
PMCPMC3830624

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.