ArticleCardiovascular diabetology2013
Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model.
Article in Cardiovascular diabetology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 24 citations in OpenAlex.
- Effects of Long-Term Regular Continuous and Intermittent Walking on Oxidative Stress, Metabolic Profile, Heart Rate Variability, and Blood Pressure in Older Adults with Hypertension.Journal of environmental and public health · 2022Trial
- Voluntary physical activity suppresses adipocyte hypertrophy through the activation of cGMP mediated pathway in a fructose-induced metabolic syndrome model in rat.European journal of nutrition · 2025Article
- Effects of Physical Training on the Myocardium of Oxariectomized LDLr Knockout Mice: MMP 2/9, Collagen I/III, Inflammation and Oxidative Stress.Arquivos brasileiros de cardiologia · 2020Article
- Swimming training induces liver adaptations to oxidative stress and insulin sensitivity in rats submitted to high-fat diet.Redox report : communications in free radical research · 2017Article
- Moderate Treadmill Exercise Training Improves Cardiovascular and Nitrergic Response and Resistance toFrontiers in physiology · 2017Article
- High fructose diet suppresses exercise-induced increase in AQP7 expression in the in vivo rat heart.Anatolian journal of cardiology · 2016Article
- Effects of non-supervised low intensity aerobic excise training on the microvascular endothelial function of patients with type 1 diabetes: a non-pharmacological interventional study.BMC cardiovascular disorders · 2016Article
- Short-term moderate exercise provides long-lasting protective effects against metabolic dysfunction in rats fed a high-fat diet.European journal of nutrition · 2015Article
- Exercise training prevents increased intraocular pressure and sympathetic vascular modulation in an experimental model of metabolic syndrome.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- Effect of mild aerobic training on the myocardium of mice with chronic Chagas disease.Biologics : targets & therapy · 2015Article
- Effect of different exercise intensities on the pancreas of animals with metabolic syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2015Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increase in fructose consumption is paralleled by a higher incidence of metabolic syndrome, and consequently, cardiovascular disease mortality. We examined the effects of 8 weeks of low intensity exercise training (LET) on metabolic, hemodynamic, ventricular and vascular morphological changes induced by fructose drinking in male rats.
methodsMale Wistar rats were divided into (n = 8 each) control (C), sedentary fructose (F) and ET fructose (FT) groups. Fructose-drinking rats received D-fructose (100 g/l). FT rats were assigned to a treadmill training protocol at low intensity (30% of maximal running speed) during 1 h/day, 5 days/week for 8 weeks. Measurements of triglyceride concentrations, white adipose tissue (WAT) and glycemia were carried out together with insulin tolerance test to evaluate metabolic profile. Arterial pressure (AP) signals were directly recorded. Baroreflex sensitivity (BS) was evaluated by the tachycardic and bradycardic responses. Right atria, left ventricle (LV) and ascending aorta were prepared to morphoquantitative analysis.
resultsLET reduced WAT (-37.7%), triglyceride levels (-33%), systolic AP (-6%), heart weight/body weight (-20.5%), LV (-36%) and aortic (-76%) collagen fibers, aortic intima-media thickness and circumferential wall tension in FT when compared to F rats. Additionally, FT group presented improve of BS, numerical density of atrial natriuretic peptide granules (+42%) and LV capillaries (+25%), as well as the number of elastic lamellae in aorta compared with F group.
conclusionsOur data suggest that LET, a widely recommended practice, seems to be particularly effective for preventing metabolic, hemodynamic and morphological disorders triggered by MS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.