Trial reportThe Annals of pharmacotherapy
Changes in cholesterol-lowering medications use over a decade in community-dwelling older adults.
Trial report in The Annals of pharmacotherapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of statin-drug interactions in older people: a systematic review.European journal of clinical pharmacology · 2016Pooled it
- Comparison of statins for primary prevention of cardiovascular disease and persistent physical disability in older adults.European journal of clinical pharmacology · 2022 · on this mapTrial
- Underprescription of Fibrate Among Patients With Diabetic Retinopathy in Perak, Malaysia.Cureus · 2024Article
- Association between knowledge and risk for cardiovascular disease among older adults: A cross-sectional study in China.International journal of nursing sciences · 2020Article
- Quantifying Unmet Need in Statin-Treated Hyperlipidemia Patients and the Potential Benefit of Further LDL-C Reduction Through an EHR-Based Retrospective Cohort Study.Journal of managed care & specialty pharmacy · 2019Article
- Changing predictors of statin initiation in US women over two decades.Pharmacoepidemiology and drug safety · 2019Article
- Association of Statin Exposure With Histologically Confirmed Idiopathic Inflammatory Myositis in an Australian Population.JAMA internal medicine · 2018Article
- Statins for Primary Prevention of Cardiovascular Events and Mortality in Older Men.Journal of the American Geriatrics Society · 2017Article
- Cost-effectiveness and population impact of statins for primary prevention in adults aged 75 years or older in the United States.Annals of internal medicine · 2015Article
- Metformin enhances nitric oxide production and diminishes Rho kinase activity in rats with hyperlipidemia.Lipids in health and disease · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundThe impact of evidence-based guidelines and controlled trial data on use of cholesterol-lowering medications in older adults is unclear.
objectiveTo examine whether utilization patterns of cholesterol-lowering medications in community-dwelling older adults changed following the release of the National Cholesterol Education Program Adult Treatment Panel III guidelines and results from the Prospective Study of Pravastatin in the Elderly at Risk in 2002.
methodsCommunity-dwelling elderly individuals who were enrolled in the Health, Aging and Body Composition Study in 1997-1998 were followed for up to 11 years. An interrupted time series analysis with multivariable generalized estimating equations (GEEs) was used to examine changes in level and trend in cholesterol-lowering medication use before and after 2002, adjusting for sociodemographics, health-related behaviors, and health status.
resultsCholesterol-lowering medication use increased nearly 3-fold from 14.9% in 1997-1998 to 42.6% in 2007-2008, with statins representing the most common class used (87-94%). Multivariable GEE results revealed no significant difference in the level of cholesterol-lowering medication use after 2002 (adjusted OR 0.95; 95% CI 0.89-1.02). Multivariable GEE results revealed that trend changes in the rate of increase in cholesterol-lowering medication declined after 2002 (adjusted ratio of ORs 0.92; 95% CI 0.89-0.95).
conclusionsThe use of cholesterol-lowering medication increased substantially over a decade in community-dwelling elderly individuals but was not related to a change in level or trend following the release of the guidelines and evidence-based data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.