ArticleAmerican journal of human genetics1990
Sample-size guidelines for linkage analysis of a dominant locus for a quantitative trait by the method of lod scores.
Article in American journal of human genetics, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Constructing High-Density Genetic Maps and Developing Sexing Markers in Northern Snakehead (Channa argus).Marine biotechnology (New York, N.Y.) · 2019Article
- Evidence for locus heterogeneity in autosomal dominant limb-girdle muscular dystrophy.American journal of human genetics · 1995Article
- Prospects for the genetics of human longevity.Human genetics · 1993Review
- Comparison of a multipoint identity-by-descent method with parametric multipoint linkage analysis for mapping quantitative traits.American journal of human genetics · 1992Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Sample-size guidelines for linkage studies of quantitative traits partially determined by a dominant major locus are needed to provide a rough estimate of the amount of pedigree material that should be sampled to map the loci that influence such traits. After pedigrees are sampled, a specific power calculation can be carried out to evaluate the linkage information provided by the sampled pedigrees. Using computer simulation, I provide sample-size guidelines for linkage studies by the method of lod scores of quantitative traits partially determined by a dominant major locus. I consider the effects of a trait model, marker characteristics, and sampling strategy, with particular attention to sampling strategy because it is the one factor which the investigator can fully control. My results suggest that linkage studies of quantitative traits are practical, particularly if the investigator chooses an efficient sampling design and an efficient strategy to select pedigrees for linkage analysis.
Indexed as
Identifiers
2378347PMC1683715What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.