ArticleThe Journal of biological chemistry2013
Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Voltage-gated potassium channels as important modulators of glucose-stimulated insulin secretion in pancreatic β-cells: insights from rodent and human studies.Frontiers in endocrinology · 2026Review
- Ion channels and actin: A tale of two friends.Histology and histopathology · 2025Review
- Article
- Integrative single-cell characterization of a frugivorous and an insectivorous bat kidney and pancreas.Nature communications · 2024Article
- Celebrities in the heart, strangers in the pancreatic beta cell: Voltage-gated potassium channels KActa physiologica (Oxford, England) · 2022Review
- Potassium channels and the development of arousal-relevant action potential trains in primary hindbrain neurons.Brain research · 2021Article
- Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells.Diabetologia · 2019Article
- GScluster: network-weighted gene-set clustering analysis.BMC genomics · 2019Article
- Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.Nucleic acids research · 2019Article
- Noninvasively evaluating the grading and IDH1 mutation status of diffuse gliomas by three-dimensional pseudo-continuous arterial spin labeling and diffusion-weighted imaging.Neuroradiology · 2018Article
- The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.Cell metabolism · 2018Article
- KThe Journal of biological chemistry · 2018Article
- Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.Diabetes · 2017Article
- Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival.PloS one · 2017Article
- A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.Molecular and cellular biology · 2016Article
- Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells.The Journal of biological chemistry · 2015Article
- β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.The Journal of clinical endocrinology and metabolism · 2014Article
- β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.Diabetes care · 2014Review
- Evolutionary analysis of voltage-gated potassium channels by Bayes method.Journal of molecular neuroscience : MN · 2014Article
- DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.Journal of autoimmunity · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent studies have shown that the pyruvate-isocitrate cycling pathway, involving the mitochondrial citrate/isocitrate carrier and the cytosolic NADP-dependent isocitrate dehydrogenase (ICDc), is involved in control of glucose-stimulated insulin secretion (GSIS). Here we demonstrate that pyruvate-isocitrate cycling regulates expression of the voltage-gated potassium channel family member Kv2.2 in islet β-cells. siRNA-mediated suppression of ICDc, citrate/isocitrate carrier, or Kv2.2 expression impaired GSIS, and the effect of ICDc knockdown was rescued by re-expression of Kv2.2. Moreover, chronic exposure of β-cells to elevated fatty acids, which impairs GSIS, resulted in decreased expression of Kv2.2. Surprisingly, knockdown of ICDc or Kv2.2 increased rather than decreased outward K(+) current in the 832/13 β-cell line. Immunoprecipitation studies demonstrated interaction of Kv2.1 and Kv2.2, and co-overexpression of the two channels reduced outward K(+) current compared with overexpression of Kv2.1 alone. Also, siRNA-mediated knockdown of ICDc enhanced the suppressive effect of the Kv2.1-selective inhibitor stromatoxin1 on K(+) currents. Our data support a model in which a key function of the pyruvate-isocitrate cycle is to maintain levels of Kv2.2 expression sufficient to allow it to serve as a negative regulator of Kv channel activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.