Trial reportDiabetes care2013
Infancy-onset dietary counseling of low-saturated-fat diet improves insulin sensitivity in healthy adolescents 15-20 years of age: the Special Turku Coronary Risk Factor Intervention Project (STRIP) study.
Trial report in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Nutrition interventions in the first 1000 days and long-term health outcomes: a systematic review.Pediatric research · 2025Pooled it
- Effects of total fat intake on bodyweight in children.The Cochrane database of systematic reviews · 2018Pooled it
- Effects of total fat intake on bodyweight in children.The Cochrane database of systematic reviews · 2018Pooled it
- Health effects of saturated and trans-fatty acid intake in children and adolescents: Systematic review and meta-analysis.PloS one · 2017Pooled it
- Randomized 20-year infancy-onset dietary intervention, life-long cardiovascular risk factors and retinal microvasculature.European heart journal · 2024Trial
- Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention-Association with Metabolic Profile from Childhood to Adulthood.Nutrients · 2021Trial
- Trial
- Longitudinal effect of 20-year infancy-onset dietary intervention on food consumption and nutrient intake: the randomized controlled STRIP study.European journal of clinical nutrition · 2019Trial
- Low-saturated-fat and low-cholesterol diet does not alter pubertal development and hormonal status in adolescents.Acta paediatrica (Oslo, Norway : 1992) · 2019Trial
- Effect of Dietary Counseling on a Comprehensive Metabolic Profile from Childhood to Adulthood.The Journal of pediatrics · 2018Trial
- Weight Gain in Infancy and Childhood Were Associated With Pubertal Development in Boys and Girls.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Combined Dyslipidemia in Children and Adolescents: a Proposed New Management Approach.Current atherosclerosis reports · 2023Review
- Prevention of atherosclerosis from childhood.Nature reviews. Cardiology · 2022Review
- Weight gain in infancy and markers of cardiometabolic health in young adulthood.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children: the PANIC study.Diabetologia · 2020Article
- Primordial prevention of cardiovascular disease.Circulation · 2015Article
- Childhood obesity and insulin resistance: how should it be managed?Current treatment options in cardiovascular medicine · 2014Article
- Role of childhood food patterns on adult cardiovascular disease risk.Current atherosclerosis reports · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe reported previously that low-saturated-fat dietary counseling started in infancy improves insulin sensitivity in healthy children 9 years of age. The aim of this study was to evaluate the effect of lifelong dietary counseling on insulin sensitivity in healthy adolescents between 15 and 20 years of age. In addition, we examined dietary fiber intake and the polyunsaturated fatty acid (PUFA)+monounsaturated (MUFA)-to-saturated fatty acid (SFA) ratio in the intervention and control adolescents and the association of these dietary factors with homeostasis model of insulin resistance (HOMA-IR). RESEARCH DESIGN AND
methodsThe study comprised adolescents participating in the randomized, controlled Special Turku Coronary Risk Factor Intervention Project (STRIP) study, which aims to guide the study participants toward a diet beneficial for cardiovascular health. HOMA-IR was assessed annually between 15 and 20 years of age (n=518; intervention, n=245; control, n=273), along with diet, BMI, pubertal status, serum cotinine concentrations, and physical activity. Dietary counseling was given biannually during the follow-up.
resultsHOMA-IR was lower (7.5% on average) in the intervention group than in the control group between 15 and 20 years of age (P=0.0051). The intervention effect was similar in girls and boys. The PUFA+MUFA-to-SFA ratio was higher (P<0.0001) and the dietary fiber (g/MJ) intake was higher (P=0.0058) in the intervention group compared with the control group. There was no association between the PUFA+MUFA-to-/SFA ratio and HOMA-IR, whereas dietary fiber intake (g/MJ) was associated with HOMA-IR in girls (P<0.0001).
conclusionsDietary counseling initiated in infancy and maintained until 20 years of age was associated with improved insulin sensitivity in adolescents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.