ArticlePloS one2013
Ryanodine Receptors Selectively Interact with L Type Calcium Channels in Mouse Taste Cells.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Nutrient Sensing by Lingual G-Protein-Coupled Taste Receptors.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Article
- Remodeling of the ryanodine receptor isoform 1 channel regulates the sweet and umami taste perception ofFundamental research · 2023Article
- Defining the role of TRPM4 in broadly responsive taste receptor cells.Frontiers in cellular neuroscience · 2023Article
- Taste Cells of the Type III Employ CASR to Maintain Steady Serotonin Exocytosis at Variable CaCells · 2022Article
- Taste Receptor Signaling.Handbook of experimental pharmacology · 2022Article
- Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation.Frontiers in human neuroscience · 2021Review
- A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli.PLoS genetics · 2020Article
- Sensing Senses: Optical Biosensors to Study Gustation.Sensors (Basel, Switzerland) · 2020Review
- Differential Effects of Diet and Weight on Taste Responses in Diet-Induced Obese Mice.Obesity (Silver Spring, Md.) · 2020Article
- The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells.Life science alliance · 2019Article
- AP1 transcription factors are required to maintain the peripheral taste system.Cell death & disease · 2016Article
- Calcium signaling in taste cells.Biochimica et biophysica acta · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWE REPORTED THAT RYANODINE RECEPTORS ARE EXPRESSED IN TWO DIFFERENT TYPES OF MAMMALIAN PERIPHERAL TASTE RECEPTOR CELLS: Type II and Type III cells. Type II cells lack voltage-gated calcium channels (VGCCs) and chemical synapses. In these cells, ryanodine receptors contribute to the taste-evoked calcium signals that are initiated by opening inositol trisphosphate receptors located on internal calcium stores. In Type III cells that do have VGCCs and chemical synapses, ryanodine receptors contribute to the depolarization-dependent calcium influx. METHODOLOGY/PRINCIPAL
findingsThe goal of this study was to establish if there was selectivity in the type of VGCC that is associated with the ryanodine receptor in the Type III taste cells or if the ryanodine receptor opens irrespective of the calcium channels involved. We also wished to determine if the ryanodine receptors and VGCCs require a physical linkage to interact or are simply functionally associated with each other. Using calcium imaging and pharmacological inhibitors, we found that ryanodine receptors are selectively associated with L type VGCCs but likely not through a physical linkage. CONCLUSIONS/SIGNIFICANCE: Taste cells are able to undergo calcium induced calcium release through ryanodine receptors to increase the initial calcium influx signal and provide a larger calcium response than would otherwise occur when L type channels are activated in Type III taste cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.