ArticleJournal of pediatric surgery2013
Synergistic effects of HB-EGF and mesenchymal stem cells in a murine model of intestinal ischemia/reperfusion injury.
Article in Journal of pediatric surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mesenchymal stem cells against intestinal ischemia-reperfusion injury: a systematic review and meta-analysis of preclinical studies.Stem cell research & therapy · 2022Pooled it
- Minimal Cube Explant Provides Optimal Isolation Condition of Mesenchymal Stem Cells from Umbilical Cord.Tissue engineering and regenerative medicine · 2022Article
- Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischemia-reperfusion injuryFrontiers in cell and developmental biology · 2022Article
- Stem Cell Therapy and Hydrogen Sulfide: Conventional or Nonconventional Mechanisms of Action?Shock (Augusta, Ga.) · 2020Article
- HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation.International journal of molecular sciences · 2019Article
- The synergistic effect of electroacupuncture and bone mesenchymal stem cell transplantation on repairing thin endometrial injury in rats.Stem cell research & therapy · 2019Article
- The HO-1-expressing bone mesenchymal stem cells protects intestine from ischemia and reperfusion injury.BMC gastroenterology · 2019Article
- Interleukin-6 Therapy Improves Intestinal Recovery Following Ischemia.The Journal of surgical research · 2019Article
- The route and timing of hydrogen sulfide therapy critically impacts intestinal recovery following ischemia and reperfusion injury.Journal of pediatric surgery · 2018Article
- Umbilical mesenchymal stromal cells provide intestinal protection through nitric oxide dependent pathways.The Journal of surgical research · 2018Article
- Stem cell therapy in necrotizing enterocolitis: Current state and future directions.Seminars in pediatric surgery · 2018Review
- Hydrogen sulfide improves intestinal recovery following ischemia by endothelial nitric oxide-dependent mechanisms.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Mesenchymal stromal cell therapy for the treatment of intestinal ischemia: Defining the optimal cell isolate for maximum therapeutic benefit.Cytotherapy · 2016Review
- Global hypoxia-ischemia induced inflammation and structural changes in the preterm ovine gut which were not ameliorated by mesenchymal stem cell treatment.Molecular medicine (Cambridge, Mass.) · 2016Article
- Harvest tissue source does not alter the protective power of stromal cell therapy after intestinal ischemia and reperfusion injury.The Journal of surgical research · 2016Article
- Synergistic Effects of Electroacupuncture and Mesenchymal Stem Cells on Intestinal Ischemia/Reperfusion Injury in Rats.Inflammation · 2016Article
- Human Adipose Stromal Cells Increase Survival and Mesenteric Perfusion Following Intestinal Ischemia and Reperfusion Injury.Shock (Augusta, Ga.) · 2016Article
- Heparin-binding EGF-like growth factor and enteric neural stem cell transplantation in the prevention of experimental necrotizing enterocolitis in mice.Pediatric research · 2015Article
- Local injection of mesenchymal stem cells protects testicular torsion-induced germ cell injury.Stem cell research & therapy · 2015Article
- HB-EGF augments the ability of mesenchymal stem cells to attenuate intestinal injury.Journal of pediatric surgery · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundWe have previously demonstrated that heparin-binding EGF-like growth factor (HB-EGF) administration protects the intestines from ischemia/reperfusion (I/R) injury in vivo. We have also shown that HB-EGF promotes mesenchymal stem cell (MSC) proliferation and migration in vitro. The goals of the current study were to examine the effects of HB-EGF and both bone marrow (BM)- and amniotic fluid (AF)-derived MSC on intestinal I/R injury in vivo. MATERIALS AND
methodsMSC were isolated from pan-EGFP mice, expanded, and purified. Pluripotency was confirmed by induced differentiation. Mice were subjected to terminal ileum I/R and received either: (1) no therapy; (2) HB-EGF; (3) BM-MSC; (4) HB-EGF+BM-MSC; (5) AF-MSC; or (6) HB-EGF+AF-MSC. MSC engraftment, histologic injury, and intestinal permeability were quantified.
resultsThere was increased MSC engraftment into injured compared to uninjured intestine for all experimental groups, with significantly increased engraftment for AF-MSC+HB-EGF compared to AF-MSC alone. Administration of HB-EGF and MSC improved intestinal histology and intestinal permeability after I/R injury. The greatest improvement was with combined administration of HB-EGF+AF-MSC.
conclusionsBoth HB-EGF alone and MSC alone can protect the intestines from I/R injury, with synergistic efficacy occurring when HB-EGF and AF-MSC are administered together.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.