Pharmacodynamic effects of adjunctive high dose atorvastatin on double dose clopidogrel in patients with high on-treatment platelet reactivity depending on diabetes mellitus status.

Mario Leoncini et al.PubMed ↗Publisher ↗

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with higher kidney outcomes

7.5×1.2× to 47×

Bigger than almost all on the map

As reported

OR 7.5, 95% CI 1.19–47.0

Correlation, not cause

Went with higher kidney outcomes

+7%+1% to +13%

Bigger than 1 in 10 on the map

As reported

OR 1.07, 95% CI 1.01–1.13

Two numbers in the abstract

the abstract, start to end

… were: atorvastatin treatment (OR = 7.5 [95% CI 1.19-47]; p = 0.032) in DM patients; PRU values (OR = 0.9 [95% CI 0.95-0.99]; p = 0.031) and creatinine clearance (OR = 1.07 [95% CI 1.008-1.13]; p = 0.025) …

← favours treatmentfavours comparator →

could be chance

Kidney outcomes

OR 7.51.19–47.0

Kidney outcomes

OR 1.071.01–1.13

StatinsAntiplatelet & anticoagulantKidney outcomes

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2 papers cite it

2014

2015

2016

2017

2018

this papercites it

The trial

NCT03331666phase 44 enrolled2018

Pharmacodynamic effects of adjunctive high dose atorvastatin on double dose clopidogrel in patients with high on-treatment platelet reactivity depending on diabetes mellitus status.

What moved togetherboth groups pooled, not the treatment’s effect

Went with higher kidney outcomes

Went with higher kidney outcomes

Two numbers in the abstract

Where each one falls

Where it lands on the map

2 papers cite it

The trial