Evidence map›Paper›PMID 23872939›Full record

Trial reportMedicine and science in sports and exercise2014

One bout of exercise alters free-living postprandial glycemia in type 2 diabetes.

Douglas J Oberlin, Catherine R Mikus, Monica L Kearney, Pamela S Hinton, Camila Manrique, Heather J Leidy, Jill A Kanaley, R Scott Rector, John P Thyfault

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicine and science in sports and exercise, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06592209 (Body Electric), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06592209 nacompletednot on this mapstarted 2023, after this paper: background citation

Body Electric: a Pragmatic Trial Evaluating Movement Breaks As a Public Health Strategy to Mitigate the Harms of Prolonged Sedentary Behavior

TypeinterventionalSponsorColumbia UniversityRan2023 to 2023Enrolled20,217ConditionsSedentary BehaviorArmsSedentary Breaks
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  15. The role of exercise and hypoxia on glucose transport and regulation.European journal of applied physiology · 2023
    Review
  16. Article
  17. Article
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  19. Review
  20. Five Evidence-Based Lifestyle Habits People With Diabetes Can Use.Clinical diabetes : a publication of the American Diabetes Association · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Douglas J Oberlin1Departments of Nutrition and Exercise Physiology and Internal Medicine, University of Missouri, Columbia, MO; 2Division of Cardiology, Duke University Medical Center, Durham, NC; 3Division of Endocrinology, University of Missouri, Columbia, MO; 4Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO; and 5Harry S Truman Memorial VA Hospital, Columbia, MO.
Catherine R Mikus
Monica L Kearney
Pamela S Hinton
Camila Manrique
Heather J Leidy
Jill A Kanaley
R Scott Rector
John P Thyfault

Funding

BLRD VA IK2 BX001299NIDDK NIH HHS R01 DK088940NIDDK NIH HHS R01DK088940
6 · The paper itself

Abstract

purposeElevated postprandial glycemic (PPG) excursions are significant risk factors for cardiovascular disease in type 2 diabetes patients. In this study, we tested if and for how many meals a single bout of exercise would reduce PPG responses to subsequent meals in type 2 diabetes (T2D) patients using a continuous glucose monitor system (CGMS).

methodsWe recruited nine sedentary (<30 min·wk(-1) of exercise) individuals with T2D (mean ± SD; body mass index = 36.0 ± 1.1 kg·m(-2), age = 60.3 ± 1.0 yr, HbA1c = 6.3% ± 0.2%). The subjects consumed a eucaloric diet (51% carbohydrate, 31% fat, and 18% protein) consisting of three meals, identical in composition, for a 2-d period while wearing a continuous glucose monitor system in two different conditions (exercise [EX], one 60-min bout at 60%-75% of heart rate reserve performed before breakfast), vs a sedentary [SED] condition). We quantified 24-h average glucose, PPG area under the curve (AUC; 4-h glucose AUC after meals), and PPG-2 h (2 h postprandial glucose).

resultsEX significantly reduced average [glucose] during the first 24-h period (P = 0.03). EX caused a reduction in PPG-AUC (P = 0.02) for all of the meals during the 2 d (main effect between conditions). A comparison between the EX and the SED conditions at each meal revealed that EX reduced PPG-AUC after the second meal of day 1 (lunch) (P = 0.04). PPG-2 h was not significantly different between EX and SED.

conclusionsAlthough a single EX bout does lower 24-h average [glucose], it only significantly lowered PPG-AUC at the second meal after the bout, suggesting that daily exercise may be needed to most effectively improve PPG at the advent of exercise training in T2D patients.

Indexed as

Area Under CurveBlood GlucoseCross-Over StudiesDiabetes Mellitus, Type 2ExerciseFemaleHumansMaleMiddle AgedMonitoring, PhysiologicPostprandial PeriodTime FactorsBlood Glucose

Identifiers

PMID23872939
PMCPMC4521618

What Socratic holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.