← Statins × cardiovascular events

TrialStroke2013

Extended-release niacin therapy and risk of ischemic stroke in patients with cardiovascular disease: the Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) trial.

Koon K Teo et al.PubMed ↗Full text ↗Publisher ↗

  • Simvastatin plus ERN (1500-2000 mg/d)no clear effectNo clear effect on fatal or nonfatal ischemic strokes.Nothing cleared the noise.

What the trial testedas reported · 3,414 people · 2013

Range includes no effect

No clear effect on fatal or nonfatal ischemic strokes

1.8×1× to 3.2×

simvastatin plus ERN (1500-2000 mg/d) vs simvastatin plus matching placebo

2 in 100 instead of 1

Bigger than 9 in 10 for cardiovascular events

As reported

HR 1.78, 95% CI 1.00–3.17

Who was studied, and how

3,414people with cardiovascular disease, in this paper

The trial randomly assignedassigned by chance

simvastatin plus ERN (1500-2000 mg/d)
simvastatin plus matching placebo

No clear effect on fatal or nonfatal ischemic strokes1.8×

randomised

the abstract, start to end

… (1.86%) in ERN arm (hazard ratio [HR], 1.78 [95% confidence interval {CI}, …

← favours treatmentfavours comparator →
could be chance
Fatal or nonfatal ischemic strokessimvastatin plus ERN (1500-2000 mg/d) vs simvastatin plus matching placebo
HR 1.781.00–3.17
StatinsCardiovascular events

Statins × cardiovascular eventshelps?replicated

unlikelylikely
0.860.86 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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13 papers cite it

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this paperpooled itcites it

The trial

NCT00120289phase 33,414 enrolled2005
Full record →Abstract, authors, funding and every citing paper · PMID 23881958