ArticleTranslational medicine @ UniSa2012
Minimally invasive Swine experimental model for the in vivo study of liver metabolism of drugs.
Article in Translational medicine @ UniSa, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
purposeTo develop a clinically relevant porcine model for the study of hepatic metabolism of drugs by means of hepatic vein catheterization. MATERIALS AND
methodsreview of literature and elaboration of a hypothesis, design of an experimental method.
resultsrecent clinical studies were conducted by withdrawing cirrhotic patients' blood from right hepatic vein during hepatic vein pressure gradient measurements. Basing on our personal clinical experience and evaluation of research needs, an experimental model is proposed.
conclusionscontemporary measurement of peripheral and hepatic concentration of drugs by peripheral vein and hepatic vein catheterization can be used to create a reliable and reproducible porcine model to study liver metabolism of drugs in vivo.
Indexed as
Identifiers
23905064PMC3728795What Socratic holds
Registered trials
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