ArticleNeurology2013
Antihypertensive medication use and risk of cognitive impairment: the Honolulu-Asia Aging Study.
Article in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.
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Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Is hypertension negatively associated with memory performance in women during climacteric? A systematic review.BMC women's health · 2025Pooled it
- Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis.Neurology · 2020Pooled it
- Effectiveness and safety of beta blockers in the management of hypertension in older adults: a systematic review to help reduce inappropriate prescribing.BMC geriatrics · 2017Pooled it
- Pooled it
- Association of Angiotensin II-Stimulating Antihypertensive Use and Dementia Risk: Post Hoc Analysis of the PreDIVA Trial.Neurology · 2021Trial
- The association between cognitive function trajectories and all-cause mortality in middle-aged and older Chinese adults with cardiovascular disease: A longitudinal study from CHARLS.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Associations of antihypertensive, antidiabetic, and antihyperlipidemic medications with cognitive performance in an Asian population.GeroScience · 2026Article
- Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization.Nature aging · 2026Article
- The Cognitive Changes Among Patients over 65 Years of Age in a Rural Area-The Preliminary Report of Protective and Predisposing Factors.Neurology international · 2025Article
- Activation of the AMPK Signaling and Brain Function: A Friend or Foe?Journal of neurochemistry · 2025Review
- Effects of SGLT2 inhibitors on cognitive impairment in elderly inpatients with heart failure with reduced ejection fraction: a prospective cohort study.BMC cardiovascular disorders · 2025Article
- Cognitive impairment in CKD patients: a guidance document by the CONNECT network.Clinical kidney journal · 2025Review
- Correlation of cognitive functions of hypertensive patients on different classes of antihypertensive drugs.Qatar medical journal · 2025Article
- Comparable cerebral cortex activity and gait performance in elderly hypertensive and healthy individuals during dual-task walking: A fNIRS study.Brain and behavior · 2024Article
- A latent clinical-anatomical dimension relating metabolic syndrome to brain structure and cognition.eLife · 2024Article
- A latent clinical-anatomical dimension relating metabolic syndrome to brain structure and cognition.bioRxiv : the preprint server for biology · 2023Article
- Heart failure-induced cognitive dysfunction is mediated by intracellular CaNature neuroscience · 2023Article
- Sleep quality mediates the relationship between systemic inflammation and neurocognitive performance.Brain, behavior, & immunity - health · 2023Article
- Hypertension and cognitive dysfunction: a narrative review.Journal of Yeungnam medical science · 2023Article
- Soluble and insoluble protein aggregates, endoplasmic reticulum stress, and vascular dysfunction in Alzheimer's disease and cardiovascular diseases.GeroScience · 2023Review
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6 authors.
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Abstract
objectiveTo determine the associations between classes of antihypertensive medication use and the risk of cognitive impairment among elderly hypertensive men.
methodsThe Honolulu-Asia Aging Study is a prospective, community-based cohort study of Japanese American men conducted in Honolulu, Hawaii. We examined 2,197 participants (mean age 77 years at cohort entry, 1991-1993, followed through September 2010) with hypertension and without dementia or cognitive impairment at baseline, who provided information on medication use. Cognitive function was assessed at 7 standardized examinations using the Cognitive Abilities Screening Instrument (CASI). Cognitive impairment was defined as a CASI score <74.
resultsA total of 854 men developed cognitive impairment (median follow-up, 5.8 years). β-Blocker use as the sole antihypertensive drug at baseline was consistently associated with a lower risk of cognitive impairment (incidence rate ratio [IRR] 0.69; 95% confidence interval [CI] 0.50-0.94), as compared with men not taking any antihypertensive medications, adjusting for multiple potential confounders. The use of diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors, or vasodilators alone was not significantly associated with cognitive impairment. Results were similar excluding those with cardiovascular disease or <1 year of follow-up, and additionally adjusting for pulse pressure, heart rate, baseline and midlife systolic blood pressure, and midlife antihypertensive treatment (IRR 0.65; 95% CI 0.45-0.94). The association between β-blocker use and cognitive impairment was stronger among men with diabetes, men aged >75 years, and those with pulse pressure ≥70 mm Hg.
conclusionsβ-blocker use is associated with a lower risk of developing cognitive impairment in elderly Japanese American men.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.