ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2013
Epigenetic basis of regeneration: analysis of genomic DNA methylation profiles in the MRL/MpJ mouse.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Insights into small-molecule neurotransmitter levels and distribution during tissue regeneration in an ear pinna model in mice.Scientific reports · 2026Article
- Examination of epigenetic inhibitor zebularine in treatment of skin wounds in healthy and diabetic mice.Journal of tissue engineering and regenerative medicine · 2022Article
- Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Cellular, Molecular, and Physiological Aspects of In Vitro Plant Regeneration.Plants (Basel, Switzerland) · 2020Review
- Article
- Possible Muscle Repair in the Human Cardiovascular System.Stem cell reviews and reports · 2017Review
- Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential.BMC genomics · 2016Article
- Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse.BMC genomics · 2015Article
- Human genome-wide expression analysis reorients the study of inflammatory mediators and biomechanics in osteoarthritis.Osteoarthritis and cartilage · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic regulation plays essential role in cell differentiation and dedifferentiation, which are the intrinsic processes involved in regeneration. To investigate the epigenetic basis of regeneration capacity, we choose DNA methylation as one of the most important epigenetic mechanisms and the MRL/MpJ mouse as a model of mammalian regeneration known to exhibit enhanced regeneration response in different organs. We report the comparative analysis of genomic DNA methylation profiles of the MRL/MpJ and the control C57BL/6J mouse. Methylated DNA immunoprecipitation followed by microarray analysis using the Nimblegen '3 × 720 K CpG Island Plus RefSeq Promoter' platform was applied in order to carry out genome-wide DNA methylation profiling covering 20 404 promoter regions. We identified hundreds of hypo- and hypermethylated genes and CpG islands in the heart, liver, and spleen, and 37 of them in the three tissues. Decreased inter-tissue diversification and the shift of DNA methylation balance upstream the genes distinguish the genomic methylation patterns of the MRL/MpJ mouse from the C57BL/6J. Homeobox genes and a number of other genes involved in embryonic morphogenesis are significantly overrepresented among the genes hypomethylated in the MRL/MpJ mouse. These findings indicate that epigenetic patterning might be a likely molecular basis of regeneration capability in the MRL/MpJ mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.