ArticleFrontiers in endocrinology2013
GPCR Heterodimerization in the Reproductive System: Functional Regulation and Implication for Biodiversity.
Article in Frontiers in endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Effects of chemosynthetic choline plasmalogens on gonadotropin secretion from bovine gonadotrophs.The Journal of reproduction and development · 2025Article
- Systematic Identification of Molecular Targets and Pathways Related to Human Organ Level Toxicity.Chemical research in toxicology · 2021Article
- Melatonin administration provokes the activity of dendritic reticular cells in the seminal vesicle of Soay ram during the non-breeding season.Scientific reports · 2021Article
- Invertebrate Gonadotropin-Releasing Hormone Receptor Signaling and Its Relevant Biological Actions.International journal of molecular sciences · 2020Review
- Menstruation: science and society.American journal of obstetrics and gynecology · 2020Review
- Discovery of new receptors regulating luteinizing hormone and follicle-stimulating hormone secretion by bovine gonadotrophs to explore a new paradigm for mechanisms regulating reproduction.The Journal of reproduction and development · 2020Review
- The five dimensions of receptor pharmacology exemplified by melatonin receptors: An opinion.Pharmacology research & perspectives · 2020Review
- Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Receptor-Receptor Interactions as a Widespread Phenomenon: Novel Targets for Drug Development?Frontiers in endocrinology · 2019Review
- Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits Gα13/RhoA-mediated Migration.Molecular cancer research : MCR · 2018Article
- Receptor-Receptor Interactions of G Protein-Coupled Receptors in the Carotid Body: A Working Hypothesis.Frontiers in physiology · 2018Article
- Invertebrate Gonadotropin-Releasing Hormone-Related Peptides and Their Receptors: An Update.Frontiers in endocrinology · 2017Review
- Dual Actions of Mammalian and Piscine Gonadotropin-Inhibitory Hormones, RFamide-Related Peptides and LPXRFamide Peptides, in the Hypothalamic-Pituitary-Gonadal Axis.Frontiers in endocrinology · 2017Article
- Heterodimerization of the prostaglandin E2 receptor EP2 and the calcitonin receptor CTR.PloS one · 2017Article
- The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components.International journal of molecular sciences · 2014Article
- Allosteric and biased g protein-coupled receptor signaling regulation: potentials for new therapeutics.Frontiers in endocrinology · 2014Review
- Posttranslational modification of intercellular messenger systems.Frontiers in endocrinology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A G protein-coupled receptor (GPCR) functions not only as a monomer or homodimer but also as a heterodimer with another GPCR. GPCR heterodimerization results in the modulation of the molecular functions of the GPCR protomer, including ligand binding affinity, signal transduction, and internalization. There has been a growing body of reports on heterodimerization of multiple GPCRs expressed in the reproductive system and the resultant functional modulation, suggesting that GPCR heterodimerization is closely associated with reproduction including the secretion of hormones and the growth and maturation of follicles and oocytes. Moreover, studies on heterodimerization among paralogs of gonadotropin-releasing hormone (GnRH) receptors of a protochordate, Ciona intestinalis, verified the species-specific regulation of the functions of GPCRs via multiple GnRH receptor pairs. These findings indicate that GPCR heterodimerization is also involved in creating biodiversity. In this review, we provide basic and current knowledge regarding GPCR heterodimers and their functional modulation, and explore the biological significance of GPCR heterodimerization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.