Evidence map›Paper›PMID 23972719›Full record

ArticleJournal of affective disorders2013

Heritability and linkage analysis of personality in bipolar disorder.

Tiffany A Greenwood, Judith A Badner, William Byerley, Paul E Keck, Susan L McElroy, Ronald A Remick, A Dessa Sadovnick, John R Kelsoe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. A genome-wide quantitative trait locus (QTL) linkage scan of NEO personality factors in Latino families segregating bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017
    Article
  5. Article
  6. Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tiffany A GreenwoodDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, Mail Code 0737, La Jolla, CA 92093, USA. Electronic address: tgreenwood@ucsd.edu.
Judith A BadnerDepartment of Psychiatry, University of Chicago, Chicago, IL, USA.
William ByerleyDepartment of Psychiatry, University of California San Francisco, San Francisco, CA, USA; San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA, USA.
Paul E KeckDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA.
Susan L McElroyDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA; Lindner Center of HOPE, Mason, OH, USA.
Ronald A RemickSt. Paul's Hospital, Vancouver, Canada.
A Dessa SadovnickUniversity of British Columbia, Vancouver, Canada.
John R KelsoeDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, Mail Code 0737, La Jolla, CA 92093, USA; San Diego Veterans Affairs Healthcare System, San Diego, CA, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA.

Funding

Genomic Association Study of Bipolar DisorderR01MH078151 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 2007 to 2009
$5.5M
Genomic studies of bipolar disorder and chromosome 22R01MH068503 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 2004 to 2008
$3.1M
PSYCHOBIOLOGICAL STUDY OF PSYCHIATRIC DISORDERSP30MH030914 · NIMH · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI GILLIN, JOHN C · 1997 to 2001
$2.4M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059567 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 1998 to 2007
$1.8M
The Convergence and Divergence of Schizophrenia and Bipolar DisorderK01MH087889 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GREENWOOD, TIFFANY A · 2010 to 2014
$858k
High Density Genome Wide Linkage Analysis of 922 Bipolar FamiliesR01MH077314 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BYERLEY, WILLIAM · 2007 to 2008
$444k
TRICYCLIC ANTIDEPRESSANTS ON COGNITIVE AND PERCEPTUAL MOTOR PERFORMANCEP50MH030914 · NIMH · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI HAUGER, RICHARD L · 1985 to 1996
–
GENETIC LINKAGE STUDIES OF BIPOLAR AFFECTIVE DISORDERR29MH047612 · NIMH · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI KELSOE, JOHN R · 1992 to 1996
–
NCRR NIH HHS R01 RR00827NIMH NIH HHS K01 MH087889NIMH NIH HHS K01-MH087889NIMH NIH HHS MH077314NIMH NIH HHS MH078151NIMH NIH HHS MH30914NIMH NIH HHS MH47612NIMH NIH HHS MH59567NIMH NIH HHS MH68503
6 · The paper itself

Abstract

backgroundThe many attempts that have been made to identify genes for bipolar disorder (BD) have met with limited success, which may reflect an inadequacy of diagnosis as an informative and biologically relevant phenotype for genetic studies. Here we have explored aspects of personality as quantitative phenotypes for bipolar disorder through the use of the Temperament and Character Inventory (TCI), which assesses personality in seven dimensions. Four temperament dimensions are assessed: novelty seeking (NS), harm avoidance (HA), reward dependence (RD), and persistence (PS). Three character dimensions are also included: self-directedness (SD), cooperativeness (CO), and self-transcendence (ST).

methodsWe compared personality scores between diagnostic groups and assessed heritability in a sample of 101 families collected for genetic studies of BD. A genome-wide SNP linkage analysis was then performed in the subset of 51 families for which genetic data was available.

resultsSignificant group differences were observed between BD subjects, their first-degree relatives, and independent controls for all but RD and PS, and all but HA and RD were found to be significantly heritable in this sample. Linkage analysis of the heritable dimensions produced several suggestive linkage peaks for NS (chromosomes 7q21 and 10p15), PS (chromosomes 6q16, 12p13, and 19p13), and SD (chromosomes 4q35, 8q24, and 18q12). LIMITATIONS: The relatively small size of our linkage sample likely limited our ability to reach genome-wide significance in this study.

conclusionsWhile not genome-wide significant, these results suggest that aspects of personality may prove useful in the identification of genes underlying BD susceptibility.

Indexed as

AdultBipolar DisorderEndophenotypesFamilyFemaleGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMajor Depressive DisorderMaleMiddle AgedPersonalityPersonality InventoryPolymorphism, Single NucleotideBipolar disorderGenetic linkageHeritabilityPersonalityTCI

Identifiers

PMID23972719
PMCPMC3797235

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.