ArticleJournal of the American College of Cardiology2013
Insulin status and vascular responses to weight loss in obesity.
Article in Journal of the American College of Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Relations of Metabolically Healthy and Unhealthy Obesity to Digital Vascular Function in Three Community-Based Cohorts: A Meta-Analysis.Journal of the American Heart Association · 2017Pooled it
- Body mass index modifies cardiovascular risk trajectory: a Chinese longitudinal cohort study.BMC public health · 2026Article
- Association of non-insulin-dependent insulin resistance indices with lower limb artery restenosis after drug-coated balloon angioplasty.Lipids in health and disease · 2024Article
- The association between triglyceride-glucose index and related parameters and risk of cardiovascular disease in American adults under different glucose metabolic states.Diabetology & metabolic syndrome · 2024Article
- Dietary lipids shape cytokine and leptin profiles in obesity-metabolic syndrome implications: A cross-sectional study.PloS one · 2024Article
- Sleeve gastrectomy improved microvascular phenotypes from obesity cohort, detected with optical coherence tomography angiography.Journal of diabetes · 2023Article
- Insulin Resistance-Varying Associations of Adiposity Indices with Cerebral Perfusion in Older Adults: A Population-Based Study.The journal of nutrition, health & aging · 2023Article
- Acute effects of singing on cardiovascular biomarkers.Frontiers in cardiovascular medicine · 2022Article
- Association of Bariatric Surgery With Vascular Outcomes.JAMA network open · 2021Article
- Insulin Resistance in Association with Thyroid Function, Psychoemotional State, and Cardiovascular Risk Factors.International journal of environmental research and public health · 2021Article
- Fasting Plasma Glucose and Coronary Heart Disease in a Rural Population of North Henan, China.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity.American journal of physiology. Endocrinology and metabolism · 2019Article
- Microcirculatory Improvement Induced by Laparoscopic Sleeve Gastrectomy Is Related to Insulin Sensitivity Retrieval.Obesity surgery · 2018Article
- WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-AAmerican journal of physiology. Heart and circulatory physiology · 2017Article
- Pathophysiology and Potential Non-Pharmacologic Treatments of Obesity or Kidney Disease Associated Refractory Hypertension.Current hypertension reports · 2017Review
- WNT5A-JNK regulation of vascular insulin resistance in human obesity.Vascular medicine (London, England) · 2016Article
- Comparable Attenuation of Sympathetic Nervous System Activity in Obese Subjects with Normal Glucose Tolerance, Impaired Glucose Tolerance, and Treatment Naïve Type 2 Diabetes following Equivalent Weight Loss.Frontiers in physiology · 2016Article
- Reduction in peripheral vascular resistance predicts improvement in insulin clearance following weight loss.Cardiovascular diabetology · 2015Article
- Forkhead box O-1 modulation improves endothelial insulin resistance in human obesity.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Visceral adiposopathy: a vascular perspective.Hormone molecular biology and clinical investigation · 2015Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThe aim of this study was to determine whether the effects of weight loss on arterial function are differentially modified by insulin status.
backgroundClinical studies suggest that plasma insulin levels may predict the extent of cardiovascular benefit achieved with weight loss in obese individuals, but mechanisms are currently unknown.
methodsWe prospectively followed 208 overweight or obese patients (body mass index [BMI] ≥25 kg/m(2)) receiving medical/dietary (48%) or bariatric surgical (52%) weight-loss treatment during a median period of 11.7 months (interquartile range: 4.6 to 13 months). We measured plasma metabolic parameters and vascular endothelial function using ultrasound at baseline and following weight-loss intervention and stratified analyses by median plasma insulin levels.
resultsPatients age 45 ± 1 years, with BMI 45 ± 9 kg/m(2), experienced 14 ± 14% weight loss during the study period. In individuals with higher baseline plasma insulin levels (above median >12 μIU/ml; n = 99), ≥10% weight loss (compared with <10%) significantly improved brachial artery macrovascular flow-mediated vasodilation and microvascular reactive hyperemia (p < 0.05 for all). By contrast, vascular function did not change significantly in the lower insulin group (≤12 μIU/ml; n = 109) despite a similar degree of weight loss. In analyses using a 5% weight loss cut point, only microvascular responses improved in the higher insulin group (p = 0.02).
conclusionsInsulin status is an important determinant of the positive effect of weight reduction on vascular function with hyperinsulinemic patients deriving the greatest benefit. Integrated improvement in both microvascular and macrovascular function was associated with ≥10% weight loss. Reversal of insulin resistance and endothelial dysfunction may represent key therapeutic targets for cardiovascular risk reduction in obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.