Evidence map›Paper›PMID 24009987›Full record

ArticleJournal of biometrics & biostatistics2013

Statistical Approaches to Combine Genetic Association Data.

Sharon M Lutz, Tasha Fingerlin, David W Fardo

Abstract read
In one paragraph

Article in Journal of biometrics & biostatistics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Statistical and Computational Methods for Genetic Diseases: An Overview.Computational and mathematical methods in medicine · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sharon M LutzDepartment of Biostatistics, University of Colorado, 13001 E. 17 St, Aurora CO 80045, USA.
Tasha Fingerlin
David W Fardo

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Metabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1M
University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI WILCOCK, DONNA M · 2006 to 2020
$23.3M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
GRADUATE TRAINING IN BIOSTATISTICST32ES007142 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Brent Andrew Coull · 1985 to 2026
$11.9M
Integrating linkage information in tests of association for rare variants in ILDR21HL113543 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FINGERLIN, TASHA E. · 2013 to 2014
$382k
NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R21 HL113543NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIA NIH HHS P30 AG028383NIEHS NIH HHS T32 ES007142
6 · The paper itself

Abstract

In an attempt to discover and unravel genetic predisposition to complex traits, new statistical methods have emerged that utilize multiple sources of data. This appeal to data aggregation is seen on various levels: across genetic variants, across genomic/biological/environmental measures and across different studies, often with fundamentally differing designs. While combining data can increase power to detect genetic variants associated with disease phenotypes, care must be taken in the design, analysis, and interpretation of such studies. Here, we explore methodologies employed to combine sources of genetic data and discuss the prospects for novel advances in the fields of statistical genetics and genetic epidemiology.

Identifiers

PMID24009987
PMCPMC3760734

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.