ArticlePloS one2013
Increased systemic Th17 cytokines are associated with diastolic dysfunction in children and adolescents with diabetic ketoacidosis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Cognitive Function Following Diabetic Ketoacidosis in Children With New-Onset or Previously Diagnosed Type 1 Diabetes.Diabetes care · 2020Trial
- Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis.The New England journal of medicine · 2018Trial
- Subclinical cardiac involvement during diabetic ketoacidosis at type 1 diabetes onset in youth: biomarker elevation, altered diastolic filling, and reduced global longitudinal strain: a prospective cohort study.Cardiovascular diabetology · 2026Observational
- The Cardiohepatic Axis in Metabolic Disease: Liver to Heart.JACC. Basic to translational science · 2025Review
- Enriched housing differentially alters allostatic load and cardiopulmonary responses to wildfire-related smoke in male and female mice.Journal of toxicology and environmental health. Part A · 2024Article
- Hypophosphatemia: A Common but Overlooked Cause of Cardiac Dysfunction in a Child with DKA.Indian journal of pediatrics · 2024Article
- Early expression of neuroinflammation in an untreated fatal case of diabetic ketoacidosis.Archives of endocrinology and metabolism · 2024Article
- Serum Troponin I Level in Children with Diabetic Ketoacidosis.The journal of Tehran Heart Center · 2022Article
- CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease.Cardiovascular diabetology · 2022Review
- Article
- Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response.Frontiers in physiology · 2021Review
- Soluble Receptor for Glycation End-products Concentration Increases Following the Treatment of Severe Diabetic KetoacidosisJournal of clinical research in pediatric endocrinology · 2020Article
- Diabetic ketoacidosis.Nature reviews. Disease primers · 2020Review
- Intracerebral matrix metalloproteinase 9 in fatal diabetic ketoacidosis.Experimental and molecular pathology · 2019Article
- Advances in the pharmacotherapy of chronic heart failure with preserved ejection fraction: an ideal opportunity for precision medicine.Expert opinion on pharmacotherapy · 2017Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diastolic dysfunction suggestive of diabetic cardiomyopathy is established in children with T1DM, but its pathogenesis is not well understood. We studied the relationships of systemic inflammatory cytokines/chemokines and cardiac function in 17 children with T1DM during and after correction of diabetic ketoacidosis (DKA). Twenty seven of the 39 measured cytokines/chemokines were elevated at 6-12 hours into treatment of DKA compared to values after DKA resolution. Eight patients displayed at least one parameter of diastolic abnormality (DA) during acute DKA. Significant associations were present between nine of the cytokine/chemokine levels and the DA over time. Interestingly, four of these nine interactive cytokines (GM-CSF, G-CSF, IL-12p40, IL-17) are associated with a Th17 mediated cell response. Both the DA and CCL7 and IL-12p40, had independent associations with African American patients. Thus, we report occurrence of a systemic inflammatory response and the presence of cardiac diastolic dysfunction in a subset of young T1DM patients during acute DKA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.