ArticleJournal of the peripheral nervous system : JPNS2013
In vivo peripheral nervous system insulin signaling.
Article in Journal of the peripheral nervous system : JPNS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Transcriptomic profiling of sciatic nerves and dorsal root ganglia reveals site-specific effects of prediabetic neuropathy.Translational research : the journal of laboratory and clinical medicine · 2024Article
- The Effects of Insulin on Immortalized Rat Schwann Cells, IFRS1.International journal of molecular sciences · 2021Article
- Disrupting insulin signaling in Schwann cells impairs myelination and induces a sensory neuropathy.Glia · 2020Article
- Modulation of Sensory Nerve Function by Insulin: Possible Relevance to Pain, Inflammation and Axon Growth.International journal of molecular sciences · 2020Review
- Deletion of the insulin receptor in sensory neurons increases pancreatic insulin levels.Experimental neurology · 2018Article
- The correlation between insulin and OCT-6 transcription factor in Schwann cells and sciatic nerve of diabetic rats.Genes & diseases · 2018Article
- Insulin Confers Differing Effects on Neurite Outgrowth in Separate Populations of Cultured Dorsal Root Ganglion Neurons: The Role of the Insulin Receptor.Frontiers in neuroscience · 2018Article
- Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats.Experimental neurology · 2017Article
- Modulation of diet-induced mechanical allodynia by metabolic parameters and inflammation.Journal of the peripheral nervous system : JPNS · 2017Article
- A Role for Insulin in Diabetic Neuropathy.Frontiers in neuroscience · 2016Review
- Activation of the insulin-signaling pathway in sciatic nerve and hippocampus of type 1 diabetic rats.Neuroscience · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Alterations in peripheral nervous system (PNS) insulin support may contribute to diabetic neuropathy (DN); yet, PNS insulin signaling is not fully defined. Here, we investigated in vivo insulin signaling in the PNS and compared the insulin responsiveness to that of muscle, liver, and adipose. Non-diabetic mice were administered increasing doses of insulin to define a dose-response relationship between insulin and Akt activation in the dorsal root ganglion (DRG) and sciatic nerve. Resulting EC50 doses were used to characterize the PNS insulin signaling time course and make comparisons between insulin signaling in the PNS and other peripheral tissues (i.e., muscle, liver, and adipose). The results demonstrate that the PNS is responsive to insulin and that differences in insulin signaling pathway activation exist between PNS compartments. At a therapeutically relevant dose, Akt was activated in the muscle, liver, and adipose at 30 min, correlating with the changes in blood glucose levels. Interestingly, the sciatic nerve showed a similar signaling profile as insulin-sensitive tissues; however, there was not a comparable activation in the DRG or spinal cord. These results present new evidence regarding PNS insulin signaling pathways in vivo and provide a baseline for studies investigating the contribution of disrupted PNS insulin signaling to DN pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.