ArticleThe Journal of cell biology2013
The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility.
Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Pushing boundaries: mechanisms enabling bacterial pathogens to spread between cells.Infection and immunity · 2024Review
- Article
- FHODs: Nuclear tethered formins for nuclear mechanotransduction.Frontiers in cell and developmental biology · 2023Review
- Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation.Journal of cell science · 2020Article
- Viral cell-to-cell spread: Conventional and non-conventional ways.Advances in virus research · 2020Review
- Hic-5 regulates Src-induced invadopodia rosette formation and organization.Molecular biology of the cell · 2019Article
- Characterization of putative proteins encoded by variable ORFs in white spot syndrome virus genome.BMC structural biology · 2019Article
- Enteropathogenic E. coli relies on collaboration between the formin mDia1 and the Arp2/3 complex for actin pedestal biogenesis and maintenance.PLoS pathogens · 2018Article
- Ultrastructure of the actin cytoskeleton.Current opinion in cell biology · 2018Review
- Septins suppress the release of vaccinia virus from infected cells.The Journal of cell biology · 2018Article
- Tissue-Specific Functions ofG3 (Bethesda, Md.) · 2018Article
- STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.Nature communications · 2018Article
- Divergent roles of β- and γ-actin isoforms during spread of vaccinia virus.Cytoskeleton (Hoboken, N.J.) · 2017Article
- Integration of linear and dendritic actin nucleation in Nck-induced actin comets.Molecular biology of the cell · 2016Article
- The diaphanous-related formins promote protrusion formation and cell-to-cell spread of Listeria monocytogenes.The Journal of infectious diseases · 2015Article
- A role for the small GTPase Rac1 in vaccinia actin-based motility.Small GTPases · 2015Review
- Review
- FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement.Nature cell biology · 2014Article
- Viral exploitation of actin: force-generation and scaffolding functions in viral infection.Virologica Sinica · 2014Review
- Formins as effector proteins of Rho GTPases.Small GTPases · 2014Review
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2 authors at 1 institution in 1 country.
Funding
Abstract
Vaccinia virus dissemination relies on the N-WASP-ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs). Here, we uncover a previously unappreciated role for the formin FHOD1 and the small GTPase Rac1 in vaccinia actin tail formation. FHOD1 depletion decreased the number of CEVs forming actin tails and impaired the elongation rate of the formed actin tails. Recruitment of FHOD1 to actin tails relied on its GTPase binding domain in addition to its FH2 domain. In agreement with previous studies showing that FHOD1 is activated by the small GTPase Rac1, Rac1 was enriched and activated at the membrane surrounding actin tails. Rac1 depletion or expression of dominant-negative Rac1 phenocopied the effects of FHOD1 depletion and impaired the recruitment of FHOD1 to actin tails. FHOD1 overexpression rescued the actin tail formation defects observed in cells overexpressing dominant-negative Rac1. Altogether, our results indicate that, to display robust actin-based motility, vaccinia virus integrates the activity of the N-WASP-ARP2/3 and Rac1-FHOD1 pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.