ArticleObesity (Silver Spring, Md.)2014
Associations of maternal pre-pregnancy and gestational body size with offspring longitudinal change in BMI.
Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review.Frontiers in endocrinology · 2022Pooled it
- Effect of maternal n-3 long-chain polyunsaturated fatty acid supplementation during pregnancy and/or lactation on adiposity in childhood: a systematic review and meta-analysis of randomized controlled trials.European journal of clinical nutrition · 2014Pooled it
- The long-term associations of perinatal obesogenic environment with offspring biological aging.American journal of epidemiology · 2025Article
- Perinatal exposures and adolescence overweight: The role of shared maternal-offspring pathways.Atherosclerosis · 2024Article
- Gestational weight change and childhood body composition trajectories from pregnancy to early adolescence.Obesity (Silver Spring, Md.) · 2022Article
- Environmental mismatch and obesity in humans: The Jerusalem Perinatal Family Follow-Up Study.International journal of obesity (2005) · 2021Article
- A Common R219K Variant of ATP-Binding Cassette Transporter A1 Gene Alters Atherometabolic Traits in Pregnant Women With Gestational Diabetes Mellitus.Frontiers in endocrinology · 2021Article
- Umbilical Cord SFRP5 Levels of Term Newborns in Relation to Normal and Excessive Gestational Weight Gain.International journal of molecular sciences · 2019Article
- Association of Maternal Prepregnancy Weight with Offspring Adiposity Throughout Adulthood over 37 Years of Follow-up.Obesity (Silver Spring, Md.) · 2019Article
- Maternal gestational weight gain and DNA methylation in young women: application of life course mediation methods.Epigenomics · 2017Article
- Mother's Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort.Scientific reports · 2017Article
- Accounting for Life-Course Exposures in Epigenetic Biomarker Association Studies: Early Life Socioeconomic Position, Candidate Gene DNA Methylation, and Adult Cardiometabolic Risk.American journal of epidemiology · 2016Article
- Cohort Profile: The Jerusalem Perinatal Family Follow-Up Study.International journal of epidemiology · 2016Article
- Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity.PloS one · 2016Article
- Racial Differences in Obesity-Related Risk Factors Between 2-Year-Old Children Born of Overweight Mothers.Journal of pediatric psychology · 2015Observational
- Parental smoking during pregnancy and offspring cardio-metabolic risk factors at ages 17 and 32.Atherosclerosis · 2014Article
- Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 4 countries.
Funding
Abstract
objectivesStudies demonstrate associations between changes in obesity-related phenotypes and cardiovascular risk. Although maternal pre-pregnancy BMI (mppBMI) and gestational weight gain (GWG) may be associated with adult offspring adiposity, no study has examined associations with obesity changes. Associations of mppBMI and GWG with longitudinal change in offspring's BMI (ΔBMI) were examined, and whether associations are explained by offspring genetics was assessed.
methodsA birth cohort of 1400 adults, with data at birth, age 17 and 32 years was used. After genotyping offspring, genetic scores, predictive of exposures and outcome were created, and linear regression models with and without scores were fit to examine the associations of mppBMI and GWG with ΔBMI.
resultsA one SD change in mppBMI and GWG was associated with a 0.83 and a 0.75 kg/m² increase in ΔBMI, respectively. The association between mppBMI and offspring ΔBMI was slightly attenuated (12%) with the addition of genetic scores. In the GWG model, a significant substantial 28.2% decrease in the coefficient was observed.
conclusionsThis study points to an association between maternal excess weight in pregnancy and offspring BMI change from adolescence to adulthood. Genetic factors may account, in part, for GWG/ΔBMI association. These findings broaden observations that maternal obesity-related phenotypes have long-term consequences for offspring health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.