ArticleWiener klinische Wochenschrift2013
Differences in the metabolic status of healthy adults with and without active brown adipose tissue.
Article in Wiener klinische Wochenschrift, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle-aged men.Diabetes, obesity & metabolism · 2017Trial
- A new method of infrared thermography for quantification of brown adipose tissue activation in healthy adults (TACTICAL): a randomized trial.The journal of physiological sciences : JPS · 2017Trial
- Serum secreted EMC10 (scEMC10) levels are inversely associated with metabolically active brown adipose tissue in humans.International journal of obesity (2005) · 2025Article
- C-Phycocyanin Extract Modulates Thermogenic and Inflammatory Markers in Brown Adipose Tissue of High-Fat Diet-Fed Animals.Molecules (Basel, Switzerland) · 2025Article
- Role of Brown Adipose Tissue in Metabolic Health and Efficacy of Drug Treatment for Obesity.Journal of clinical medicine · 2024Article
- Metabolic Effects of Brown Adipose Tissue Activity Due to Cold Exposure in Humans: A Systematic Review and Meta-Analysis of RCTs and Non-RCTs.Biomedicines · 2024Review
- Thermogenic Brown Fat in Humans: Implications in Energy Homeostasis, Obesity and Metabolic Disorders.The world journal of men's health · 2023Review
- Obesity and the risk of cardiometabolic diseases.Nature reviews. Cardiology · 2023Review
- Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach.BMC bioinformatics · 2022Article
- The Role of Thermogenic Fat Tissue in Energy Consumption.Current issues in molecular biology · 2022Review
- Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis.Diabetes & metabolism journal · 2021Review
- Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway.Nutrition & metabolism · 2021Article
- Brown Adipose Tissue and Its Role in Insulin and Glucose Homeostasis.International journal of molecular sciences · 2021Review
- Neuropeptide Y Plays an Important Role in the Relationship Between Brain Glucose Metabolism and Brown Adipose Tissue Activity in Healthy Adults: A PET/CT Study.Frontiers in endocrinology · 2021Article
- Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men.Frontiers in endocrinology · 2020Review
- Contributors to Metabolic Disease Risk Following Spinal Cord Injury.Current physical medicine and rehabilitation reports · 2016Article
- The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults.Lipids in health and disease · 2016Article
- The role of active brown adipose tissue in human metabolism.European journal of nuclear medicine and molecular imaging · 2016Article
- Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance.Frontiers in physiology · 2015Review
- Brown adipose tissue activation is inversely related to central obesity and metabolic parameters in adult human.PloS one · 2015Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have proven the existence of active brown adipose tissue (BAT) in adults; however, its effect on systematic metabolism remains unclear.
aimThe current study was designed to investigate the differences in the metabolic profiles of healthy adults with and without active BAT using positron emission tomography-computed tomography (PET-CT) scans in the un-stimulated state.
methodsA cross-sectional analysis was performed to assess the health of adults using PET-CT whole-body scans at Huashan Hospital Medical Centre between November 2009 and May 2010. A total of 62 healthy adults with active BAT were enrolled in the BAT-positive group. For each positive subject, a same-gender individual who underwent PET-CT the same day and who had no detectable BAT was chosen as the negative control. Body composition was measured, and blood samples were collected for assays of metabolic profiles and other biomarkers.
resultsIn both the male and female groups, BAT-positive individuals were younger and had lower body mass indexes, fasting insulin, insulin resistance, and leptin, but a greater level of high-density lipoprotein cholesterol compared with the negative controls. In the male group, body fat content and levels of tumor necrosis factor-α were significantly lower in the BAT-positive than in the negative control group.
conclusionsThe healthy adults with active BAT in an un-stimulated state had favorable metabolic profiles suggesting that active BAT may be a potential target for preventing and treating obesity and other metabolic disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.